The use of implantable biomedical devices for the repair of peripheral nervous system injuries shows great promises for a complete recovery of the physiological nerve function. The neutralization of pro-fibrotic factors like TGF-β1 and the promotion of an oriented growth of the transected neurites are of pivotal importance in nerve regeneration. This study focuses on the investigation of the diffusion kinetics of a non specific antibody in nerve guidance channels based on the use of natural compounds. They have been found to be able to work as a depot of antibodies but the release kinetics resulted to be rather fast.
Drug delivery for nerve tissue regeneration
CANEVA SOUMETZ, FEDERICO;GIACOMINI, MAURO;PASTORINO, LAURA;RUGGIERO, CARMELINA
2004-01-01
Abstract
The use of implantable biomedical devices for the repair of peripheral nervous system injuries shows great promises for a complete recovery of the physiological nerve function. The neutralization of pro-fibrotic factors like TGF-β1 and the promotion of an oriented growth of the transected neurites are of pivotal importance in nerve regeneration. This study focuses on the investigation of the diffusion kinetics of a non specific antibody in nerve guidance channels based on the use of natural compounds. They have been found to be able to work as a depot of antibodies but the release kinetics resulted to be rather fast.
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