Salvia miniata Fernald [1] is a Mexican species whose aerial part exudate showed herbicide activity against Papaver rhoeas L. and Avena sativa L. in a preliminary test [2]. Some diterpenes isolated from Salvia miniata had phytotoxic activity against the germination and the subsequent growth of Papaver rhoeas L. and Avena sativa L., thus indicating that these compounds likely contribute to the activity of the total exudate mixture [3]. The surface exudate, obtained by rinsing the plant material with CH2Cl2, and subjected to repeated column chromatography on Sephadex LH-20 and silica gel and to HPLC-MS and MS2 experiments followed by semi-preparative RP-HPLC, yielded a new clerodane diterpenoid (1), identified by IR and NMR analysis, including TOCSY, COSY, HSQC, HMBC and ROESY experiments, and ESI-TRAP-MS and HR-MS analysis. References: 1. Epling, C. (1940) A Revision of Salvia, subgenus Calosphace. In: Repertorium Specierum Novarum Regni Vegetabilis. Vol.110. Fedde F., University of California Press: Berkley, California.
A new clerodane diterpenoid from Salvia miniata Fernald.
BISIO, ANGELA;GIACOMELLI, EMANUELA;DAMONTE, GIANLUCA;SALIS, ANNALISA;ROMUSSI, GIOVANNI;CAFAGGI, SERGIO;
2011-01-01
Abstract
Salvia miniata Fernald [1] is a Mexican species whose aerial part exudate showed herbicide activity against Papaver rhoeas L. and Avena sativa L. in a preliminary test [2]. Some diterpenes isolated from Salvia miniata had phytotoxic activity against the germination and the subsequent growth of Papaver rhoeas L. and Avena sativa L., thus indicating that these compounds likely contribute to the activity of the total exudate mixture [3]. The surface exudate, obtained by rinsing the plant material with CH2Cl2, and subjected to repeated column chromatography on Sephadex LH-20 and silica gel and to HPLC-MS and MS2 experiments followed by semi-preparative RP-HPLC, yielded a new clerodane diterpenoid (1), identified by IR and NMR analysis, including TOCSY, COSY, HSQC, HMBC and ROESY experiments, and ESI-TRAP-MS and HR-MS analysis. References: 1. Epling, C. (1940) A Revision of Salvia, subgenus Calosphace. In: Repertorium Specierum Novarum Regni Vegetabilis. Vol.110. Fedde F., University of California Press: Berkley, California.
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