A method for detecting by means of antibodies the presence and quantity of some substrates of gamma - secretase and of fragments of said substrates, obtained both by the action of said gamma - secretase or of other proteases, in biological samples isolated from the human body. The invention also relates to a kit for the detection of said substrates and fragments, as well as their antibodies to be used in the method and in the kit for the diagnosis of diseases such as Alzheimer's, Down syndrome and cancers. In particular , the antibodies are produced against specific C - terminal sequences of the protein LRP8 and its fragments.
METHOD FOR DETECTING THE PRESENCE AND QUANTITY OF THE LRP8 RECEPTOR AND OF ITS PROTEOLYTIC FRAGMENTS , DETECTION KIT AND RELATED ANTIBODIES
Aldo Pagano;Tullio FLORIO
2022-03-10
Abstract
A method for detecting by means of antibodies the presence and quantity of some substrates of gamma - secretase and of fragments of said substrates, obtained both by the action of said gamma - secretase or of other proteases, in biological samples isolated from the human body. The invention also relates to a kit for the detection of said substrates and fragments, as well as their antibodies to be used in the method and in the kit for the diagnosis of diseases such as Alzheimer's, Down syndrome and cancers. In particular , the antibodies are produced against specific C - terminal sequences of the protein LRP8 and its fragments.
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