IRIS
SONCINI, DEBORA
 Distribuzione geografica
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Continente #
EU - Europa 3.785
Totale 3.785
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Nazione #
IT - Italia 3.785
Totale 3.785
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Città #
Genova 2.844
Rapallo 517
Genoa 416
Bordighera 8
Totale 3.785
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Nome #
Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of AKT-mediated gene repression 171
1222 POSTER Chemical Screening for Potentiators of Lapatinib Activity in Human Breast Cancer 169
1221 POSTER Chemical-genetic Screenings for Synthetic-lethal Interactions in Breast Cancer 164
APO866 increases antitumor activity of cyclosporin - A by inducing mitochondrial and endoplasmic reticulum stress in leukemia cells 164
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells vulnerability to DNA-damaging agents 162
Ras-induced resistance to lapatinib is overcome by MEK inhibition 140
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells. 139
Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors As Therapeutics: Rationales, Controversies, Clinical Experience. 137
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects 132
Catastrophic NAD(+) Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE 128
Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques. 126
CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells. 124
Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity. 123
EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition 122
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells 116
Synthetic lethality-based therapeutics: perspectives for applications in colorectal cancer. 115
Fasting potentiates the anticancer activity of tyrosin kinase inhibitors by strenghtening MAPK signalling inhibition. 113
Chemical-genetic Screenings for Synthetic-lethal Interactions in Breast Cancer 111
Dynamic simulations of pathways downstream of ERBB-family, including mutations and treatments. Concordance with experimental results. 111
Treatment with the CC chemokine-binding protein Evasin-4 improves post-infarction myocardial injury and survival in mice. 107
Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells. 102
Exploiting tumor vulnerabilities: NAD+-depleting agents combined with anti-tumor drugs as innovative strategy to treat hematological malignancies 99
The new small tyrosine-kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs 99
Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors 94
HDAC INHIBITORS SYNERGISTICALLY ENHANCE AP0866 ACTIVITY IN HUMAN LEUKEMIA CELLS: EVIDENCE FOR CONVERGING MECHANISMS OF SIRT1 INHIBITION 87
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses. 83
Chemical Screening for Potentiators of Lapatinib Activity in Human Breast Cancer 82
Long non-coding RNA NEAT1 targeting impairs the DNA repair machinery and triggers anti-tumor activity in multiple myeloma 82
SIRT6 inhibition as a novel approach for treating Acute Myeloid Leukemia 78
Synergistic Interaction Between P-glycoprotein Inhibitors and APO866 in Primary Leukemic Cells 71
Potent Synergistic Activity of the NAD plus Synthesis Inhibitor APO866 and of the Apoptosis Inducer TRAIL in in Vitro and Ex Vivo Cellular Models of Non Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia. 56
Amino acid depletion triggered by L-asparaginase sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death 53
Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment 51
Dual NAMPT and BTK targeting leads to synergistic killing of Waldenström macroglobulinemia cells regardless of MYD88 and CXCR4 somatic mutation status 45
CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NAD+-Lowering Agents 40
Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment 39
Sirtuin 6 Regulates the Activation of the ATP/Purinergic Axis in Endothelial Cells 17
Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma 11
Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia 6
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses 4
Targeting the immune microenvironment in Waldenström Macroglobulinemia via halting the CD40/CD40-ligand axis 1
Totale 3.874
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Categoria #
all - tutte 10.905
article - articoli 10.905
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 21.810
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019176 0 0 0 0 0 0 0 0 0 0 91 85
2019/20201.094 48 23 39 103 102 151 149 94 100 151 106 28
2020/2021372 27 28 22 24 47 27 28 39 26 44 41 19
2021/2022466 15 21 35 74 18 36 22 97 20 39 28 61
2022/2023629 55 63 11 95 105 74 8 46 86 9 66 11
2023/2024321 10 29 17 55 40 83 14 53 13 4 3 0
Totale 3.874