IRIS
BRAMBILLA, GIOVANNI
 Distribuzione geografica
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Continente #
EU - Europa 10.231
Totale 10.231
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Nazione #
IT - Italia 10.231
Totale 10.231
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Città #
Genova 8.209
Rapallo 1.041
Genoa 803
Vado Ligure 161
Bordighera 17
Totale 10.231
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Nome #
Keynote comment: nitrosatable drugs, cancer, and guidelines for genotoxicity 167
FORMATION OF DNA-DAMAGING NITROSO COMPOUNDS BY INTERACTION OF DRUGS WITH NITRITE. A PRELIMINARY SCREENING FOR DETECTING POTENTIALLY HAZARDOUS DRUGS. 152
DNA DAMAGE INDUCED IN RATS BY ORAL ADMINISTRATION OF CHLORDIAZEPOXIDE PLUS SODIUM NITRITE OR OF N-NITROSOCHLORDIAZEPOXIDE 145
Formation of DNA-damaging N-nitroso compounds from the interaction of calcium-channel blockers with nitrite 143
Are some progestins genotoxic liver carcinogens? 140
Increased frequency of micronucleated kidney cells in rats exposed to halogenated anaesthetics. 139
DNA DAMAGE IN LIVER, COLON, STOMACH, LUNG AND KIDNEY OF BALB/C MICE TREATED WITH 1,2-DIMETHYLHYDRAZINE. 137
Testing of metoclopramide and procainamide for their ability to induce genotoxic effects in cultured mammalian cells. 135
GENOTOXIC EFFECTS IN RODENTS GIVEN HIGH ORAL DOSES OF RANITIDINE AND SODIUM NITRITE. 131
Comparison of micronuclei frequencies in mono-, bi- and poly-nucleated lymphocytes from subjects of a residential suburb and subjects living near a metallurgical plant 130
Comparative study of DNA repair induced by cyproterone acetate, chlormadinone acetate and megestrol acetate in primary cultures of human and rat hepatocytes. 128
Genotoxicity and carcinogenicity studies of antihypertensive agents 128
Discrepancies between use of antihypertensive drugs and guidelines indications: pharmacoeconomic implications 128
Studies on genotoxicity and carcinogenicity of antibacterial, antiviral, antimalarial and antifungal drugs. 128
Comparison in human and rat hepatocytes of the DNA-damaging activity of five chemicals probably carcinogenic to humans. 127
Pharmaceutical companies provide insufficient information about genotoxicity and carcinogenicity assays 126
DNA-damaging activity of biotic and xenobiotic aldehydes in Chinese hamster ovary cells. 124
AN IN VIVO MICRONUCLEUS ASSAY FOR DETECTING THE CLASTOGENIC EFFECT IN RAT KIDNEY CELLS. 123
Genotoxicity testing of chloramphenicol in rodent and human cells 120
Update of carcinogenicity studies in animals and humans of 535 marketed pharmaceuticals 120
GENOTOXICITY OF CIMETIDINE IN PRIMARY CULTURES OF RAT HEPATOCYTES. 119
DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate. 119
REDUCTION OF DNA REPAIR EFFICIENCY DURING THE INITIAL PHASE OF RAT LIVER CARCINOGENESIS. 118
A STUDY OF THE POTENTIAL GENOTOXICITY OF CIMETIDINE USING HUMAN HEPATOCYTE PRIMARY CULTURES: DISCREPANCY FROM RESULTS OBTAINED IN RAT HEPATOCYTES. 117
Higher sensitivity for the detection of chemically-induced DNA damage: role of DNA unfolding in determining alkaline elution rate 117
Ipriflavone inhibits osteoclast differentiation in parathyroid transplanted parietal bone of rats 117
Use of human thyroid cell primary cultures for genotoxicity studies 117
DNA DAMAGE INDUCED BY SEVEN N-NITROSOCOMPOUNDS IN PRIMARY CULTURES OF HUMAN AND RAT KIDNEY CELLS. 116
Update on genotoxicity and carcinogenicity testing of 472 marketed pharmaceuticals 116
Comparison of micronucleus formation in mouse bone marrow and spleen. 113
The effect of benzenediols and benzenetriols on the nitrosation of propranolol depends on the position of hydroxyl groups on the benzene ring 113
Grain counting in the in vitro hepatocyte DNA-repair assay. 113
Species, sex and inter-individual differences in DNA repair induced by nine sex steroids in primary cultures of rat and human hepatocytes 113
DNA-DAMAGING AND MUTAGENIC PROPERTIES OF 2-NITROPROPANE IN RODENTS AND HUMAN CELLS. 112
Human hepatocyte primary cultures in toxicity assessment 112
DNA alkaline elution: physical basis of the elution process and validation of this method as a screening procedure to identify chemical carcinogens. 112
Methylglyoxal-induced DNA-protein cross-links and cytotoxicity in Chinese hamster ovary cells 112
Effects of mono-, di- and tri-hydroxybenzoic acids on the nitrosation of propranolol: structure-activity relationship 111
Genotoxicity and carcinogenicity studies of benzodiazepines 110
INDUCTION OF DNA FRAGMENTATION AND DNA REPAIR SYNTHESIS IN HUMAN AND RAT HEPATOCYTES BY DIETHYLSTILBESTROL. 110
Is lipid peroxidation associated with DNA damage? 109
Nitrosation of propranolol under simulated gastric conditions. 108
ALKALINE ELUTION ASSAY AS A POTENTIALLY USEFUL METHOD FOR ASSESSING DNA DAMAGE INDUCED "IN VIVO" BY DIAZOALKANES. 107
Genotoxicity and carcinogenicity studies of antihistamines. 107
Cynnamaldehyde-induced micronuclei in rodent liver 107
Mutagenicity in V79 Chinese hamster cells of n-alkanals produced by lipid peroxidation 105
DNA damage induced by 3,3’-dimethoxybenzidine in liver and urinary bladder cells of rats and humans 105
DNA FRAGMENTATION BY N-NITROSODIMETHYLAMINE AND METHYL METHANESULFONATE IN HUMAN HEPATOCYTE PRIMARY CULTURES. 103
Physico-chemical model for DNA alkaline elution: new experimental evidence and differential role of DNA length, chain flexibility and superpacking 103
Genotoxicity testing of potassium canrenoate in cultured rat and human cells 103
Genotoxicity and carcinogenicity studies of bronchodilators and antiasthma drugs 102
Comparison of the sensitivity of human and rat hepatocytes to genotoxic effects of metronidazole 102
DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by chemicals carcinogenic to the rat thyroid 101
Arylamine drugs: genotoxic-carcinogenic activity of NO-derivatives 101
Induction of sister-chromatid exchanges in Chinese hamster ovary cells of biotic ketoaldehyde methylglyoxal. 100
Correlation between induction of DNA fragmentation in urinary bladder cells from rats and humans and tissue-specific carcinogenic activity. 100
Lack of evidence of omeprazole genotoxicity in Sprague-Dawley rats. 100
Genotoxicity of N-nitrosochlordiazepoxide in cultured mammalian cells. 99
Evaluation of omeprazole genotoxicity in a battery of in vitro and in vivo assays 97
DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by four rat thyroid carcinogens 97
Genotoxic and carcinogenic effects of gastrointestinal drugs 97
Cytotoxic and Genotoxic activity of 1,3-dichloropropene in cultured mammalian cells. 97
DNA DAMAGE AND REPAIR IN MOUSE TISSUES FOLLOWING PROCARBAZINE ADMINISTRATION. 96
GENOTOXIC ACTIVITY OF 1,3-DICHLOROPROPENE IN A BATTERY OF IN VIVO SHORT-TERM TESTS. 96
COMPARATIVE EFFECTS OF CHEENODEOXYCHOLIC (CDCA) AND URSODEOXYCHOLIC ACID (UDCA) IN PREGNAT RATS. 95
Human hepatocytes in genotoxicity assays 95
Guidelines for the clinical use of albumin; comparison of use in two Italian hospitals and a third hospital without guidelines. 95
DNA damage induced by nitrosated ranitidine in cultured mammalian cells. 95
Genotoxic and carcinogenic risk to humans of drug-nitrite interaction products. 94
DNA DAMAGE AND REPAIR INDUCED IN RAT HEPATOCYTE PRIMARY CULTURES BY FIVE ANTIHISTAMINES AND THEIR NITROSATION PRODUCTS. 93
Evaluation of DNA-damaging, clastogenic and promoting activities of metoclopramide and procainamide in rats. 93
Induction of micronuclei and of enzyme-altered foci in the liver of female rats exposed to progesterone and three synthetic progestins. 92
The questionable use of antihypertensive drugs in the Italian Liguria Region in the year 2003 91
Genotoxicity and carcinogenicity studies of analgesics, anti-inflammatory drugs and antipyretics. 90
Correlation between induction of DNA fragmentation and micronuclei formation in kidney cells from rats and human and tissue-specific carcinogenic activity. 89
Evaluation in a battery of in vivo assays of four in vitro genotoxins proved to be noncarcinogens in rodents. 88
DNA-DAMAGING ACTIVITY OF TRIPELENNAMINE IN PRIMARY CULTURES OF HUMAN HEPATOCYES. 87
Correlation between induction of DNA fragmentation in lung cell from rats and humans and carcinogenicity activity 87
Failure of the standard battery of short-term tests in detecting some rodent and human genotoxic carcinogens 85
DNA damage induced by 4,4'-methylenedianiline in primary cultures of hepatocytes and thyreocytes from rats and humens 82
DNA damage and micronuclei induced in rat and human kidney cells by six chemicals carcinogenic to the rat kidney 82
QUANTITATIVE CORRELATION AMONG DNA DAMAGING POTENCY OF N-NITROSO COMPOUNDS AND THEIR POTENCY IN INDUCING TUMOR GROWTH AND BACTERIAL MUTATIONS. 81
Viscoelastic properties of native DNA from intact nuclei of mammalian cells. Higher-order DNA packing and cell function 80
COMPARATIVE STUDY OF DNA DAMAGE AND REPAIR INDUCED BY TEN N-NITROSO COMPOUNDS IN PRIMARY CULTURES OF HUMAN AND RAT HEPATOCYTES. 78
DNA fragmentation by 2-nitropropane in rat tissues, and effects of the modulation of biotransformation processes. 76
Sequential analysis of DNA damage and repair during the development of carcinogen-induced rat liver hyperplastic lesions 75
DNA fragmentation, DNA repair and apoptosis induced in primary rat hepatocytes by dienogest, dydrogesterone and 1,4,6-androstatriene-17beta-ol-3-one acetate 75
CYTOTOXIC, DNA-DAMAGING AND MUTAGENIC PROPERTIES OF 2,6-DIMETHOXY-1,4-BENZOQUINONE, FORMED BY DIMETHOPHRINE-NITRITE INTERACTION. 74
DNA-DAMAGING ACTIVITY "IN VIVO" AND BACTERIAL MUTAGENICITY OF SIXTEEN HYDRAZINE DERIVATIVES AS RELATED QUANTITATIVELY TO THEIR CARCINOGENICITY. 73
Induction and promotion of gamma-glutamiltranspeptidase-positive foci in the rat liver by methylglyoxal 71
Genotoxic and carcinogenic effects of antipsycotics and antidepressants 69
Genotoxicity and carcinogenicity testing of pharmaceuticals: Correlations between induction of DNA lesions and carcinogenic activity 69
Formation of the N-nitroso derivatives of six beta-adrenergic blocking agents and their genotoxic effects in rat and human hepatocytes. 68
Low clastogenic activity in vivo of the N-nitrosoderivatives of five (-adrenergic-blocking drugs proved to be potent genotoxins in vitro 67
COMPARISON OF DNA ALKYLATION, FRAGMENTATION, AND REPAIR IN MATERNAL AND FETAL TISSUES OF PREGNANT RATS TREATED WITH A SINGLE DOSE OF ETHYL METHANESULFONATE, ETHYL-N-NITROSOUREA, N-NITROSODIMETHYLAMINE, AND METHYL-N-NITROSOUREA. 64
DNA damage in tissues of rat treated with potassium canrenoate 61
GENOTOXIC ACTIVITY OF FIVE ANTIDEPRESSANT HYDRAZINES IN A BACTERY OF "IN VIVO" AND "IN VITRO" SHORT-TERM TESTS. 58
Genotoxic effects of alfa-hexachlorocyclohexane in primary cultures of rodents and human hepatocytes 57
Induction of micronuclei and inhibition of enzyme-altered foci in the liver of female rats treated with cyproterone acetate, chlormadinone acetate or megestrol acetate 57
In vitro and in vivo testing of hydralazine genotoxicity. 50
Totale 10.236
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Categoria #
all - tutte 26.690
article - articoli 26.164
book - libri 256
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 270
Totale 53.380
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.680 0 0 140 167 271 317 435 182 245 468 333 122
2020/2021637 32 65 48 56 29 63 20 68 61 65 56 74
2021/20221.232 21 138 105 110 53 69 62 316 32 103 70 153
2022/20231.237 116 91 25 145 203 232 0 100 230 4 70 21
2023/2024620 36 81 9 87 37 202 22 42 24 10 19 51
2024/2025169 20 135 14 0 0 0 0 0 0 0 0 0
Totale 10.269