IRIS
BRAMBILLA, GIOVANNI
 Distribuzione geografica
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Continente #
EU - Europa 9.992
Totale 9.992
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Nazione #
IT - Italia 9.992
Totale 9.992
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Città #
Genova 8.209
Rapallo 1.041
Genoa 725
Bordighera 17
Totale 9.992
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Nome #
Keynote comment: nitrosatable drugs, cancer, and guidelines for genotoxicity 164
FORMATION OF DNA-DAMAGING NITROSO COMPOUNDS BY INTERACTION OF DRUGS WITH NITRITE. A PRELIMINARY SCREENING FOR DETECTING POTENTIALLY HAZARDOUS DRUGS. 147
Formation of DNA-damaging N-nitroso compounds from the interaction of calcium-channel blockers with nitrite 142
DNA DAMAGE INDUCED IN RATS BY ORAL ADMINISTRATION OF CHLORDIAZEPOXIDE PLUS SODIUM NITRITE OR OF N-NITROSOCHLORDIAZEPOXIDE 140
Increased frequency of micronucleated kidney cells in rats exposed to halogenated anaesthetics. 137
DNA DAMAGE IN LIVER, COLON, STOMACH, LUNG AND KIDNEY OF BALB/C MICE TREATED WITH 1,2-DIMETHYLHYDRAZINE. 136
Are some progestins genotoxic liver carcinogens? 136
Testing of metoclopramide and procainamide for their ability to induce genotoxic effects in cultured mammalian cells. 134
GENOTOXIC EFFECTS IN RODENTS GIVEN HIGH ORAL DOSES OF RANITIDINE AND SODIUM NITRITE. 128
Comparison of micronuclei frequencies in mono-, bi- and poly-nucleated lymphocytes from subjects of a residential suburb and subjects living near a metallurgical plant 128
Comparative study of DNA repair induced by cyproterone acetate, chlormadinone acetate and megestrol acetate in primary cultures of human and rat hepatocytes. 127
Discrepancies between use of antihypertensive drugs and guidelines indications: pharmacoeconomic implications 127
Studies on genotoxicity and carcinogenicity of antibacterial, antiviral, antimalarial and antifungal drugs. 127
Genotoxicity and carcinogenicity studies of antihypertensive agents 126
Pharmaceutical companies provide insufficient information about genotoxicity and carcinogenicity assays 125
DNA-damaging activity of biotic and xenobiotic aldehydes in Chinese hamster ovary cells. 122
Comparison in human and rat hepatocytes of the DNA-damaging activity of five chemicals probably carcinogenic to humans. 121
AN IN VIVO MICRONUCLEUS ASSAY FOR DETECTING THE CLASTOGENIC EFFECT IN RAT KIDNEY CELLS. 119
Genotoxicity testing of chloramphenicol in rodent and human cells 119
GENOTOXICITY OF CIMETIDINE IN PRIMARY CULTURES OF RAT HEPATOCYTES. 118
Update of carcinogenicity studies in animals and humans of 535 marketed pharmaceuticals 118
DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate. 117
Ipriflavone inhibits osteoclast differentiation in parathyroid transplanted parietal bone of rats 116
Higher sensitivity for the detection of chemically-induced DNA damage: role of DNA unfolding in determining alkaline elution rate 115
REDUCTION OF DNA REPAIR EFFICIENCY DURING THE INITIAL PHASE OF RAT LIVER CARCINOGENESIS. 114
Update on genotoxicity and carcinogenicity testing of 472 marketed pharmaceuticals 114
A STUDY OF THE POTENTIAL GENOTOXICITY OF CIMETIDINE USING HUMAN HEPATOCYTE PRIMARY CULTURES: DISCREPANCY FROM RESULTS OBTAINED IN RAT HEPATOCYTES. 113
DNA DAMAGE INDUCED BY SEVEN N-NITROSOCOMPOUNDS IN PRIMARY CULTURES OF HUMAN AND RAT KIDNEY CELLS. 112
The effect of benzenediols and benzenetriols on the nitrosation of propranolol depends on the position of hydroxyl groups on the benzene ring 112
Grain counting in the in vitro hepatocyte DNA-repair assay. 111
Use of human thyroid cell primary cultures for genotoxicity studies 111
DNA-DAMAGING AND MUTAGENIC PROPERTIES OF 2-NITROPROPANE IN RODENTS AND HUMAN CELLS. 110
Species, sex and inter-individual differences in DNA repair induced by nine sex steroids in primary cultures of rat and human hepatocytes 110
Effects of mono-, di- and tri-hydroxybenzoic acids on the nitrosation of propranolol: structure-activity relationship 109
Genotoxicity and carcinogenicity studies of benzodiazepines 109
Human hepatocyte primary cultures in toxicity assessment 109
Comparison of micronucleus formation in mouse bone marrow and spleen. 109
Methylglyoxal-induced DNA-protein cross-links and cytotoxicity in Chinese hamster ovary cells 109
INDUCTION OF DNA FRAGMENTATION AND DNA REPAIR SYNTHESIS IN HUMAN AND RAT HEPATOCYTES BY DIETHYLSTILBESTROL. 107
Genotoxicity and carcinogenicity studies of antihistamines. 106
Nitrosation of propranolol under simulated gastric conditions. 106
DNA alkaline elution: physical basis of the elution process and validation of this method as a screening procedure to identify chemical carcinogens. 106
ALKALINE ELUTION ASSAY AS A POTENTIALLY USEFUL METHOD FOR ASSESSING DNA DAMAGE INDUCED "IN VIVO" BY DIAZOALKANES. 105
Cynnamaldehyde-induced micronuclei in rodent liver 105
Is lipid peroxidation associated with DNA damage? 105
Mutagenicity in V79 Chinese hamster cells of n-alkanals produced by lipid peroxidation 103
DNA damage induced by 3,3’-dimethoxybenzidine in liver and urinary bladder cells of rats and humans 103
Genotoxicity testing of potassium canrenoate in cultured rat and human cells 102
DNA FRAGMENTATION BY N-NITROSODIMETHYLAMINE AND METHYL METHANESULFONATE IN HUMAN HEPATOCYTE PRIMARY CULTURES. 101
Physico-chemical model for DNA alkaline elution: new experimental evidence and differential role of DNA length, chain flexibility and superpacking 101
Induction of sister-chromatid exchanges in Chinese hamster ovary cells of biotic ketoaldehyde methylglyoxal. 99
DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by chemicals carcinogenic to the rat thyroid 99
Lack of evidence of omeprazole genotoxicity in Sprague-Dawley rats. 99
Genotoxicity and carcinogenicity studies of bronchodilators and antiasthma drugs 99
Genotoxicity of N-nitrosochlordiazepoxide in cultured mammalian cells. 98
Correlation between induction of DNA fragmentation in urinary bladder cells from rats and humans and tissue-specific carcinogenic activity. 97
Comparison of the sensitivity of human and rat hepatocytes to genotoxic effects of metronidazole 97
Evaluation of omeprazole genotoxicity in a battery of in vitro and in vivo assays 95
Arylamine drugs: genotoxic-carcinogenic activity of NO-derivatives 95
DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by four rat thyroid carcinogens 95
Genotoxic and carcinogenic effects of gastrointestinal drugs 95
DNA DAMAGE AND REPAIR IN MOUSE TISSUES FOLLOWING PROCARBAZINE ADMINISTRATION. 94
Guidelines for the clinical use of albumin; comparison of use in two Italian hospitals and a third hospital without guidelines. 94
GENOTOXIC ACTIVITY OF 1,3-DICHLOROPROPENE IN A BATTERY OF IN VIVO SHORT-TERM TESTS. 94
Cytotoxic and Genotoxic activity of 1,3-dichloropropene in cultured mammalian cells. 94
DNA damage induced by nitrosated ranitidine in cultured mammalian cells. 94
Genotoxic and carcinogenic risk to humans of drug-nitrite interaction products. 93
Human hepatocytes in genotoxicity assays 93
Evaluation of DNA-damaging, clastogenic and promoting activities of metoclopramide and procainamide in rats. 92
DNA DAMAGE AND REPAIR INDUCED IN RAT HEPATOCYTE PRIMARY CULTURES BY FIVE ANTIHISTAMINES AND THEIR NITROSATION PRODUCTS. 91
Induction of micronuclei and of enzyme-altered foci in the liver of female rats exposed to progesterone and three synthetic progestins. 91
The questionable use of antihypertensive drugs in the Italian Liguria Region in the year 2003 89
COMPARATIVE EFFECTS OF CHEENODEOXYCHOLIC (CDCA) AND URSODEOXYCHOLIC ACID (UDCA) IN PREGNAT RATS. 88
Correlation between induction of DNA fragmentation and micronuclei formation in kidney cells from rats and human and tissue-specific carcinogenic activity. 87
Genotoxicity and carcinogenicity studies of analgesics, anti-inflammatory drugs and antipyretics. 87
Evaluation in a battery of in vivo assays of four in vitro genotoxins proved to be noncarcinogens in rodents. 86
Correlation between induction of DNA fragmentation in lung cell from rats and humans and carcinogenicity activity 85
DNA-DAMAGING ACTIVITY OF TRIPELENNAMINE IN PRIMARY CULTURES OF HUMAN HEPATOCYES. 84
Failure of the standard battery of short-term tests in detecting some rodent and human genotoxic carcinogens 83
DNA damage induced by 4,4'-methylenedianiline in primary cultures of hepatocytes and thyreocytes from rats and humens 80
DNA damage and micronuclei induced in rat and human kidney cells by six chemicals carcinogenic to the rat kidney 80
QUANTITATIVE CORRELATION AMONG DNA DAMAGING POTENCY OF N-NITROSO COMPOUNDS AND THEIR POTENCY IN INDUCING TUMOR GROWTH AND BACTERIAL MUTATIONS. 78
Viscoelastic properties of native DNA from intact nuclei of mammalian cells. Higher-order DNA packing and cell function 78
COMPARATIVE STUDY OF DNA DAMAGE AND REPAIR INDUCED BY TEN N-NITROSO COMPOUNDS IN PRIMARY CULTURES OF HUMAN AND RAT HEPATOCYTES. 75
DNA fragmentation by 2-nitropropane in rat tissues, and effects of the modulation of biotransformation processes. 75
Sequential analysis of DNA damage and repair during the development of carcinogen-induced rat liver hyperplastic lesions 74
DNA fragmentation, DNA repair and apoptosis induced in primary rat hepatocytes by dienogest, dydrogesterone and 1,4,6-androstatriene-17beta-ol-3-one acetate 72
CYTOTOXIC, DNA-DAMAGING AND MUTAGENIC PROPERTIES OF 2,6-DIMETHOXY-1,4-BENZOQUINONE, FORMED BY DIMETHOPHRINE-NITRITE INTERACTION. 71
Induction and promotion of gamma-glutamiltranspeptidase-positive foci in the rat liver by methylglyoxal 70
DNA-DAMAGING ACTIVITY "IN VIVO" AND BACTERIAL MUTAGENICITY OF SIXTEEN HYDRAZINE DERIVATIVES AS RELATED QUANTITATIVELY TO THEIR CARCINOGENICITY. 70
Genotoxic and carcinogenic effects of antipsycotics and antidepressants 68
Genotoxicity and carcinogenicity testing of pharmaceuticals: Correlations between induction of DNA lesions and carcinogenic activity 68
Formation of the N-nitroso derivatives of six beta-adrenergic blocking agents and their genotoxic effects in rat and human hepatocytes. 67
Low clastogenic activity in vivo of the N-nitrosoderivatives of five (-adrenergic-blocking drugs proved to be potent genotoxins in vitro 63
COMPARISON OF DNA ALKYLATION, FRAGMENTATION, AND REPAIR IN MATERNAL AND FETAL TISSUES OF PREGNANT RATS TREATED WITH A SINGLE DOSE OF ETHYL METHANESULFONATE, ETHYL-N-NITROSOUREA, N-NITROSODIMETHYLAMINE, AND METHYL-N-NITROSOUREA. 62
DNA damage in tissues of rat treated with potassium canrenoate 60
Induction of micronuclei and inhibition of enzyme-altered foci in the liver of female rats treated with cyproterone acetate, chlormadinone acetate or megestrol acetate 56
GENOTOXIC ACTIVITY OF FIVE ANTIDEPRESSANT HYDRAZINES IN A BACTERY OF "IN VIVO" AND "IN VITRO" SHORT-TERM TESTS. 55
Genotoxic effects of alfa-hexachlorocyclohexane in primary cultures of rodents and human hepatocytes 54
In vitro and in vivo testing of hydralazine genotoxicity. 49
Totale 10.003
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Categoria #
all - tutte 23.622
article - articoli 23.168
book - libri 218
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 236
Totale 47.244
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019472 0 0 0 0 0 0 0 0 0 0 259 213
2019/20202.871 97 94 140 167 271 317 435 182 245 468 333 122
2020/2021637 32 65 48 56 29 63 20 68 61 65 56 74
2021/20221.232 21 138 105 110 53 69 62 316 32 103 70 153
2022/20231.237 116 91 25 145 203 232 0 100 230 4 70 21
2023/2024550 36 81 9 87 37 202 22 42 24 10 0 0
Totale 10.030