BRUNO, OLGA
 Distribuzione geografica
Continente #
EU - Europa 921
Totale 921
Nazione #
IT - Italia 921
Totale 921
Città #
Genova 595
Genoa 174
Rapallo 143
Bordighera 9
Totale 921
Nome #
Synthesis of new pyrazolo[3,4-d]pyrimidines 6-alkyl substituted Bcr-Abl tyrosine kinase inhibitors, file e268c4c8-78c2-a6b7-e053-3a05fe0adea1 118
Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease., file e268c4c7-a189-a6b7-e053-3a05fe0adea1 99
The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein Kinase (DMPK)1 as a novel angiogenesis target, file e268c4ca-1e7c-a6b7-e053-3a05fe0adea1 86
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles, file e268c4cc-6ece-a6b7-e053-3a05fe0adea1 85
null, file e268c4cc-1bb2-a6b7-e053-3a05fe0adea1 80
null, file e268c4cc-3bab-a6b7-e053-3a05fe0adea1 67
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors, file e268c4c7-06ec-a6b7-e053-3a05fe0adea1 64
Synthesis and pharmacological evaluation of 5H-[1]benzopyrano[4,3-d]pyrimidines effective as antiplatelet/analgesic agents, file e268c4c5-f892-a6b7-e053-3a05fe0adea1 43
Synthesis and biological evaluation of neutrophilic inflammation inhibitors, file e268c4c6-10e8-a6b7-e053-3a05fe0adea1 33
Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions, file e268c4c5-f6c4-a6b7-e053-3a05fe0adea1 25
The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein Kinase (DMPK)1 as a novel angiogenesis target, file e268c4ca-2031-a6b7-e053-3a05fe0adea1 19
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation, file e268c4c6-14dd-a6b7-e053-3a05fe0adea1 15
Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea (PETT) Derivatives., file e268c4c5-eab5-a6b7-e053-3a05fe0adea1 12
New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets, file e268c4cd-3ce3-a6b7-e053-3a05fe0adea1 11
Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones , file e268c4c6-11eb-a6b7-e053-3a05fe0adea1 10
Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells, file e268c4c6-13d5-a6b7-e053-3a05fe0adea1 10
Biological evaluation of pyrazolyl-urea and dihydro-imidazopyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma, file e268c4cc-e362-a6b7-e053-3a05fe0adea1 9
2-Aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity, file e268c4c5-fa05-a6b7-e053-3a05fe0adea1 8
Novel insights on the molecular mechanism of action of the anti-angiogenic pyrazolyl-urea GeGe-3 by functional proteomics, file e268c4cd-fd3f-a6b7-e053-3a05fe0adea1 8
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities, file e268c4c5-f8fe-a6b7-e053-3a05fe0adea1 7
Synthesis and biological evaluation of N-pyrazolyl-N'-alkyl/benzyl/phenylureas: a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis, file e268c4c5-faff-a6b7-e053-3a05fe0adea1 6
Synthesis, biological activities and pharmacokinetic properties of new fluorinated derivatives of selective PDE4D inhibitors, file e268c4c6-5b9e-a6b7-e053-3a05fe0adea1 6
Pyrazole and imidazo[1,2-b]pyrazole derivatives as new potential anti-tuberculosis agents., file e268c4ca-74f8-a6b7-e053-3a05fe0adea1 6
Pyrazolyl-Ureas as Interesting Scaffold in Medicinal Chemistry, file e268c4cc-7192-a6b7-e053-3a05fe0adea1 6
Insight into GEBR‐32a: Chiral Resolution, Absolute Configuration and Enantiopreference in PDE4D Inhibition, file e268c4cd-0c2c-a6b7-e053-3a05fe0adea1 6
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis, file c9e7b88d-b001-4598-af9b-31a93fcffab6 5
2-Phenyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives: New potent inhibitors of fMLP-induced neutrophil chemotaxis, file e268c4c5-fa2a-a6b7-e053-3a05fe0adea1 5
Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis, file e268c4c9-3bd9-a6b7-e053-3a05fe0adea1 5
Molecular bases of PDE4D inhibition by GEBR-library compounds, file e268c4c9-d026-a6b7-e053-3a05fe0adea1 5
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment, file e268c4ca-5c41-a6b7-e053-3a05fe0adea1 4
New series of pyrazoles and imidazo‐pyrazoles targeting different cancer and inflammation pathways, file e268c4ce-8947-a6b7-e053-3a05fe0adea1 4
GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses., file e268c4c5-f98e-a6b7-e053-3a05fe0adea1 3
Antiproliferative activity of new 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives toward the human epidermoid carcinoma A431 cell line, file e268c4c6-0060-a6b7-e053-3a05fe0adea1 3
Relative Stereochemistry of a Diterpene from Salvia cinnabarina., file e268c4c6-04c2-a6b7-e053-3a05fe0adea1 3
Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics, file e268c4ca-5c3f-a6b7-e053-3a05fe0adea1 3
The Pyrazolyl-Urea Gege3 Inhibits the Activity of ANXA1 in the Angiogenesis Induced by the Pancreatic Cancer Derived EVs, file e268c4ce-3d62-a6b7-e053-3a05fe0adea1 3
Relative Stereochemistry of a Diterpene from Salvia cinnabarina, file e268c4c5-fd9c-a6b7-e053-3a05fe0adea1 2
Synthesis and antiproliferative activity of basic thioanalogues of merbarone, file e268c4c6-01d3-a6b7-e053-3a05fe0adea1 2
Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors, file e268c4c6-124d-a6b7-e053-3a05fe0adea1 2
Identification of novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice, file e268c4c6-14e2-a6b7-e053-3a05fe0adea1 2
Phosphodiesterase isoform-specific expression induced by traumatic brain injury, file e268c4c6-164d-a6b7-e053-3a05fe0adea1 2
Synthesis, Biological Evaluation, and Molecular Modeling of New 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-Dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) Related Phosphodiesterase 4D (PDE4D) Inhibitors., file e268c4c6-19eb-a6b7-e053-3a05fe0adea1 2
Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D, file e268c4c6-b597-a6b7-e053-3a05fe0adea1 2
Molecular bases of PDE4D inhibition by GEBR-library compounds, file e268c4c9-d027-a6b7-e053-3a05fe0adea1 2
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles, file e268c4ca-6a42-a6b7-e053-3a05fe0adea1 2
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies, file e268c4cb-05c0-a6b7-e053-3a05fe0adea1 2
Design and synthesis of 4,5,6,7‐tetrahydro‐1H‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors, file e268c4cb-1c1f-a6b7-e053-3a05fe0adea1 2
Discovery of New Antiproliferative Imidazopyrazole Acylhydrazones Able To Interact with Microtubule Systems, file e268c4cc-8ad9-a6b7-e053-3a05fe0adea1 2
Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors, file e268c4cd-d96e-a6b7-e053-3a05fe0adea1 2
Synthesis, functional proteomics and biological evaluation of new 5-pyrazolyl ureas as potential anti-angiogenic compounds, file e268c4ce-3c88-a6b7-e053-3a05fe0adea1 2
Erratum: Correction: Biological evaluation of pyrazolyl-urea and dihydro-imidazo-pyrazolyl-urea derivatives as potential anti-angiogenetic agents in the treatment of neuroblastoma (Oncotarget), file 9839634e-0091-4430-bf37-abec70cf68db 1
Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation, file e268c4c5-f237-a6b7-e053-3a05fe0adea1 1
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: parallel synthesis, molecular modelling and structure-activity relationship studies on analogues of O-(2-phenylethyl)-N-phenylthiocarbamate, file e268c4c5-f610-a6b7-e053-3a05fe0adea1 1
Parallel one-pot synthesis and structure-activity relationship study of symmetric formimidoester disulfides as a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors, file e268c4c5-f73f-a6b7-e053-3a05fe0adea1 1
6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis, file e268c4c5-f8c9-a6b7-e053-3a05fe0adea1 1
Synthesis of new 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted and antiplatelet/antiphlogistic activities evaluation, file e268c4c6-06c8-a6b7-e053-3a05fe0adea1 1
Aminoethers of (+)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-6-hydroxyimine with hypotensive activity, file e268c4c6-093f-a6b7-e053-3a05fe0adea1 1
Aminoethers of (+)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]-octan-6-hydroxyimine with hypotensive activity, file e268c4c6-0940-a6b7-e053-3a05fe0adea1 1
1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors, file e268c4c6-13da-a6b7-e053-3a05fe0adea1 1
Preparation of pyrazolo[3,4-d]pyrimidines and pyrrolo[2,3-d]pyrimidines for treatment of bone related diseases and tumors., file e268c4c7-026a-a6b7-e053-3a05fe0adea1 1
GEBR-32A, A NEW PROMISING PDE4D INHIBITOR FOR TREATMENT OF ALZHEIMER'S DISEASE, file e268c4ca-6cfd-a6b7-e053-3a05fe0adea1 1
Totale 921
Categoria #
all - tutte 1.773
article - articoli 1.592
book - libri 0
conference - conferenze 178
curatela - curatele 0
other - altro 0
patent - brevetti 3
selected - selezionate 0
volume - volumi 0
Totale 3.546


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202096 7 0 6 2 0 0 9 11 27 13 12 9
2020/2021140 11 11 6 8 4 11 16 21 6 26 11 9
2021/2022172 14 4 32 5 10 6 7 7 11 12 51 13
2022/2023163 5 11 34 24 9 37 6 12 2 5 14 4
2023/2024155 1 1 5 6 6 1 25 108 2 0 0 0
Totale 921