IRIS
SPALLAROSSA, ANDREA
 Distribuzione geografica
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Continente #
EU - Europa 8.600
Totale 8.600
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Nazione #
IT - Italia 8.600
Totale 8.600
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Città #
Genova 6.163
Rapallo 1.041
Genoa 759
Bordighera 637
Totale 8.600
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Nome #
Synthesis, SAR and molecular modelling studies of acylthiocarbamates and their parent thiocarbamates as potent non-nucleoside reverse transcriptase inhibitors related to PETT derivatives 286
Structural studies on prokaryotic sulfurtransferases 279
Studi Cristallografici di Complessi tra Transcrittasi Inversa di HIV-1 e Derivati Tiocarbammici a Scheletro Ftalimmidico, Inibitori Non Nucleosidici Correlati ai Derivati PETT. 259
6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis 156
A persulfurated cysteine promotes active site reactivity in Azotobacter vinelandii Rhodanese 144
A Successful Application of Parallel Synthesis to Computer-Assisted Structural Optimization of New Leads Targeting Human Immunodeficiency Virus-1 Reverse Transcriptase. The Case of Acylthiocarbamates and Thiocarbamates 131
Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents 130
Synthesis and biological evaluation of (acyl)hydrazones and thiosemicarbazones obtained via in situ condensation of iminium salts with nitrogen-containing nucleophiles 127
Expression and crystallographic characterization of the extracellular domain of human Natural Killer cell triggering receptor NKp46 126
Hydrophilic and amphiphilic water-soluble dendrimer prodrugs suitable for parenteral administration of a non-soluble non-nucleoside HIV-1 reverse transcriptase inhibitor thiocarbamate derivative 126
N-acylated and N,N'-diacylated imidazolidine-2-thione derivatives and N,N'-diacylated tetrahydropyrimidine-2(1H)-thione analogues: synthesis and antiproliferative activity. 118
Hemopexin: the primary specific carrier of plasma heme 116
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 1: parallel synthesis, molecular modelling and structure-activity relationship studies on O-[2-(hetero)arylethyl]-N-phenylthiocarbamates 115
Unconventional stereoselective one-pot synthesis of Knoevenagel-type indoles via in situ condensation of iminium salts with active methylene reagents 114
Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions 113
Parallel one-pot synthesis and structure-activity relationship study of symmetric formimidoester disulfides as a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors 113
Anthrax toxin: a tripartite lethal combination 113
Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents 111
Rational design, synthesis and biological evaluation of new 1,5-diarylpyrazole derivatives as CB1 receptor antagonists, structurally related to rimonabant 111
Identification of novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice 110
Crystallization and preliminary crystallographic characterization of the extracellular Ig-like domain of human natural killer cell activating receptor NKp44 110
Crystal structures of HIV-1 reverse transcriptase in complexes with thiocarbamate non-nucleoside inhibitors 105
The three-dimensional structure of NK cell receptor NKp44, a triggering partner in natural cytotoxicity 105
Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7 105
The "Rhodanese" fold and catalytic mechanism of 3-mercaptopyruvate sulfurtransferases: Crystal structure of SseA from Escherichia coli 104
Inhibition of Azotobacter vinelandii rhodanese by NO-donors 103
Exploring the binding features of rimonabant analogues and acyclic CB1 antagonists: docking studies and QSAR analysis 102
Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents 102
(Hetero)aroyl esters of 2-(N-phthalimido)ethanol and analogues: parallel synthesis, anti-HIV-1 activity and cytotoxicity 101
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: parallel synthesis, molecular modelling and structure-activity relationship studies on analogues of O-(2-phenylethyl)-N-phenylthiocarbamate 100
Two Novel GPER Agonists Induce Gene Expression Changes and Growth Effects in Cancer Cells. 100
Unprecedented one-pot stereoselective synthesis of Knoevenagel-type derivatives via in situ condensation of N-methyleniminium salts of ethylenethiourea and ethyleneurea with active methylene reagents 98
"One-pot" synthesis of N-acyl-N-phenylcarbamate derivatives endowed with anti-HIV and/or antiproliferative activities 97
Crystal structure of the extracellular domain of the human natural killer cell activating receptor NKp44 97
New selective phosphodiesterase 4D inhibitors differently acting on long, short, and supershort isoforms 97
Synthesis and antiproliferative activity of basic thioanalogues of merbarone 97
Acylthiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking studies and ligand-based CoMFA and CoMSIA analyses 94
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses 93
The three-dimensional structure of NK cell receptor NKp44, a triggering partner in natural cytotoxicity 92
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses 90
X-ray analysis of HIV-1 reverse transcriptase in complex with thiocarbamates: structure-based design and synthesis of new analogues 89
Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea (PETT) Derivatives. 88
Design, synthesis, SAR, and molecular modeling studies of acylthiocarbamates: a novel series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors structurally related to phenethylthiazolylthiourea derivatives 88
Characterization data of water-soluble hydrophilic and amphiphilic dendrimers prodrugs for delivering bioactive chemical entities otherwise non soluble. 88
Human rhinovirus 3C protease: a cysteine protease showing the trypsin(ogen)-like fold 86
Synthesis and anti-HIV-1 activity of PETT structurally related O-substituted acyl (aryl) thiocarbamates 86
Unprecedented one-pot synthesis of pharmaceutical interest derivatives via in situ condensation of heterocyclic iminium salts with nitrogen nucleophiles 86
Crystals of GlpE, a 12 kDa sulfurtransferase from Escherichia coli, display 1.06 Å resolution diffraction: a preliminary report 86
5-Substituted derivatives of 6-amino-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one as a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 85
Novel modifications in the series of O-(2-phthalimidoethyl)-N-substituted thiocarbamates and their ring-opened congeners as non-nucleoside HIV-1 reverse transcriptase inhibitors 85
Structure of the human NK cell triggering receptor NKp46 ectodomain 84
The bovine basic pancreatic trypsin inhibitor (Kunitz inhibitor): a milestone protein 84
The phosphoryl transfer reaction. Model of the HPr~P~IIA-Ntr protein complex 77
Non-PAMAM amino acids-modified dendrimers nanoparticles for enhancing water-solubility of insoluble bioactive molecules: our state of the art 76
Anthrax toxin: structure-function relationships 76
Homology modeling in tandem with 3D-QSAR analyses: a computational approach to depict the agonist binding site of the human CB2 receptor. 72
Molecular docking of the Escherichia coli PTS system 69
Parallel synthesis of O-phenoxyethyl and O-adamantyl N-acyl thiocarbamates endowed with antiproliferative activity. 69
One-pot Stereoselective Synthesis of Knoevenageltype Derivatives Via Condensation of N-Methyleniminium Salts of Ethylenethiourea and Ethyleneurea with Active Methylene Reagents. 69
Efetti della orto, meta, para sostituzione della porzione N-fenilica di O-(2-ftalimmido)etil-2-tienocarbammati sull'attività anti-HIV-1 67
Modellazioni strutturali in O-[2-(N-ftalimmido)etil] Acil(Aril)tiocarbammati, inibitori non nucleosidici della trascrittasi inversa di HIV-1 66
Parallel synthesis, molecular modelling and further structure-activity relationship studies of new acylthiocarbamates as potent non-nucleoside HIV-1 reverse transcriptase inhibitors 65
Computational approaches for the design and chemical synthesis of novel F508del correctors in the treatment of cystic fibrosis 65
Synthesis of indole imminun salts as key-intermediates in a convergent multi-step one-pot stereoselective synthesis of new potent antiproliferative Knoevenagel-type agent 64
Capitolo 19 - Agenti cardiovascolari 64
A novel potent non-nucleoside reverse transcriptase inhibitor acylthiocarbamate derivative with extensive intramolecular pi-pi interactions 61
Escherichia coli GlpE is a prototype sulfurtransferase for the single-domain rhodanese homology superfamily 60
Virtual screening and structure based drug design of new Fes/Fps kinase domain inhibitors. 59
SseA, a 3-mercaptopyruvate sulfurtransferase from Escherichia coli: crystallization and preliminary crystallographic data 59
Sintesi parallela one-pot di disolfuri dimeri di tiocarbammati, una nuova potente classe di inibitori non nucleosidici della transcrittasi inversa 57
Capitolo 18 - Farmaci attivi sul sistema renale 57
Modulazioni Strutturali in O-[2-(N-Ftalimmido)etil] Acil(Aril)Tiocarbammati, Inibitori Non-Nucleosidici della Transcrittasi Inversa di HIV-1 55
Exploring the binding features of rimonabant analogues and acyclic CB1 antagonists: docking studies and 3D-QSAR analysis 55
Reattivita' di accettori di Michael atipici con nucleofili azotati 54
Synthesis and anti-HIV-1 activity of thiocarbamates, isosteres of PETT derivatives 52
Modulazioni Strutturali del Sistema Ftalimmidico di N-Aril Tiocarbammati, Inibitori Non-Nucleosidici della Transcrittasi Inversa di HIV-1 52
Studies on the catalitic activity of Azotobacter vinelandii rhodanese 52
Sintesi di Esteri Tienopirimidinici ad Attività Antiproliferativa 50
Capitolo 14 - Anticonvulsivanti 50
Assessing the chemical cross-reaction from cefixime and some non-steroidal anti-inflammatory agents in a soluble formulation 49
Characterization of water soluble dendrimer formulations of an insoluble thiocarbamate derivative with moderate anti HIV-1 activity: an overview 49
Progettazione e Sintesi di Nuovi O-[2-(N-Ftalimmido)etil]-N-(4-Cloro- e 4-Metil-Fenil)-N-Aciltiocarbammati, Inibitori Non Nucleosidici della Trancrittasi Inversa del Virus HIV-1 Attivi a Concentrazioni Nanomolari 48
Computational studies of the binding mode and 3D-QSAR analyses of symmetric formimidoester disulfides: a new class of non-nucleoside HIV-1 reverse transcriptase inhibitors 48
Synthesis and SAR studies of novel merbarone analogues 46
Bicyclic basic merbarone analogues as antiproliferative agents 45
Sintesi Convergente “One-Pot” di Aciltiocarbammati ad Attività Antiproliferativa 44
Synthesis and prelimary docking studies of new colchicine-benzotriazole hybrid compounds 44
Non-receptor tyrosine kinase Fes as a target in oncology 43
Sintesi di tiocarbammati bioisosteri della trovirdina con attivita' antiretrovirale 43
BRD9-targeting PROTACs: design, synthesis and biological evaluation 40
Hydrophilic and amphiphilic water-soluble dendrimer formulations of a not-soluble thiocarbamate derivative with moderate anti HIV activity for biomedical applications. 34
Pharmacophore and pharmacokinetic filtering tools guiding for the design and synthesis of novel thiazole-containing and VX-809 hybrid derivatives as F508del correctors. 34
Successful Dendrimer and Liposome-Based Strategies to Solubilize an Antiproliferative Pyrazole Otherwise Not Clinically Applicable 34
Btk inhibitors: a medicinal chemistry and drug delivery perspective 34
Valorization and Potential Antimicrobial Use of Olive Mill Wastewater (OMW) from Italian Olive Oil Production 34
Insights into the Pharmacological Activity of the Imidazo-Pyrazole Scaffold 33
Effetti della orto, meta e para Sostituzione della Porzione N-Fenilica di O-(2-Ftalimmidoetil)-2-tenoilcarbammati sull' Attività anti-HIV-1 33
Synthesis and biological evaluation of new pyrazole carbohydrazides as antiproliferative and antioxidant agents. 32
Potent and Broad-Spectrum Bactericidal Activity of a Nanotechnologically Manipulated Novel Pyrazole 31
One-Pot Synthesis and Antiproliferative Activity of Highly Functionalized Pyrazole Derivatives 30
Totale 8.425
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Categoria #
all - tutte 22.916
article - articoli 14.190
book - libri 0
conference - conferenze 7.666
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 1.060
Totale 45.832
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019419 0 0 0 0 0 0 0 0 0 88 184 147
2019/20202.200 100 50 115 107 201 231 324 117 176 406 288 85
2020/2021467 36 34 31 33 32 48 21 45 49 56 41 41
2021/20221.196 30 92 79 118 35 71 78 317 55 97 76 148
2022/20231.258 120 93 10 144 195 208 13 101 227 5 132 10
2023/20241.228 45 130 24 112 61 82 44 672 43 15 0 0
Totale 8.765