SPALLAROSSA, ANDREA
 Distribuzione geografica
Continente #
EU - Europa 6919
Totale 6919
Nazione #
IT - Italia 6919
Totale 6919
Città #
Genova 6163
Rapallo 582
Genoa 174
Totale 6919
Nome #
6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis 137
A persulfurated cysteine promotes active site reactivity in Azotobacter vinelandii Rhodanese 126
Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents 122
A Successful Application of Parallel Synthesis to Computer-Assisted Structural Optimization of New Leads Targeting Human Immunodeficiency Virus-1 Reverse Transcriptase. The Case of Acylthiocarbamates and Thiocarbamates 117
Synthesis and biological evaluation of (acyl)hydrazones and thiosemicarbazones obtained via in situ condensation of iminium salts with nitrogen-containing nucleophiles 114
Expression and crystallographic characterization of the extracellular domain of human Natural Killer cell triggering receptor NKp46 114
N-acylated and N,N'-diacylated imidazolidine-2-thione derivatives and N,N'-diacylated tetrahydropyrimidine-2(1H)-thione analogues: synthesis and antiproliferative activity. 112
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Hydrophilic and amphiphilic water-soluble dendrimer prodrugs suitable for parenteral administration of a non-soluble non-nucleoside HIV-1 reverse transcriptase inhibitor thiocarbamate derivative 106
null 105
Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents 104
Parallel one-pot synthesis and structure-activity relationship study of symmetric formimidoester disulfides as a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors 104
Inhibition of Azotobacter vinelandii rhodanese by NO-donors 103
null 103
Hemopexin: the primary specific carrier of plasma heme 102
Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions 101
Two Novel GPER Agonists Induce Gene Expression Changes and Growth Effects in Cancer Cells. 100
Anthrax toxin: a tripartite lethal combination 99
Identification of novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice 99
Unconventional stereoselective one-pot synthesis of Knoevenagel-type indoles via in situ condensation of iminium salts with active methylene reagents 99
null 98
Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7 97
The "Rhodanese" fold and catalytic mechanism of 3-mercaptopyruvate sulfurtransferases: Crystal structure of SseA from Escherichia coli 96
The three-dimensional structure of NK cell receptor NKp44, a triggering partner in natural cytotoxicity 95
Crystal structures of HIV-1 reverse transcriptase in complexes with thiocarbamate non-nucleoside inhibitors 93
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Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents 89
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors: docking-based CoMFA and CoMSIA analyses 88
Synthesis and antiproliferative activity of basic thioanalogues of merbarone 87
null 87
"One-pot" synthesis of N-acyl-N-phenylcarbamate derivatives endowed with anti-HIV and/or antiproliferative activities 86
null 86
(Hetero)aroyl esters of 2-(N-phthalimido)ethanol and analogues: parallel synthesis, anti-HIV-1 activity and cytotoxicity 86
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: parallel synthesis, molecular modelling and structure-activity relationship studies on analogues of O-(2-phenylethyl)-N-phenylthiocarbamate 84
null 84
The three-dimensional structure of NK cell receptor NKp44, a triggering partner in natural cytotoxicity 81
Human rhinovirus 3C protease: a cysteine protease showing the trypsin(ogen)-like fold 79
Structure of the human NK cell triggering receptor NKp46 ectodomain 79
null 79
Structure-based Design, Parallel Synthesis, SAR and Molecular Modelling Studies of Thiocarbamates, New Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Isosteres of Phenethylthiazolylthiourea (PETT) Derivatives. 78
Crystal structure of the extracellular domain of the human natural killer cell activating receptor NKp44 78
Structural studies on prokaryotic sulfurtransferases 78
The bovine basic pancreatic trypsin inhibitor (Kunitz inhibitor): a milestone protein 78
Unprecedented one-pot synthesis of pharmaceutical interest derivatives via in situ condensation of heterocyclic iminium salts with nitrogen nucleophiles 77
Synthesis and anti-HIV-1 activity of PETT structurally related O-substituted acyl (aryl) thiocarbamates 76
X-ray analysis of HIV-1 reverse transcriptase in complex with thiocarbamates: structure-based design and synthesis of new analogues 73
5-Substituted derivatives of 6-amino-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one as a new class of potent inhibitors of interleukin 8-induced neutrophil chemotaxis 72
Crystals of GlpE, a 12 kDa sulfurtransferase from Escherichia coli, display 1.06 Å resolution diffraction: a preliminary report 72
The phosphoryl transfer reaction. Model of the HPr~P~IIA-Ntr protein complex 71
Homology modeling in tandem with 3D-QSAR analyses: a computational approach to depict the agonist binding site of the human CB2 receptor. 71
Characterization data of water-soluble hydrophilic and amphiphilic dendrimers prodrugs for delivering bioactive chemical entities otherwise non soluble. 67
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Synthesis, SAR and molecular modelling studies of acylthiocarbamates and their parent thiocarbamates as potent non-nucleoside reverse transcriptase inhibitors related to PETT derivatives 61
Modellazioni strutturali in O-[2-(N-ftalimmido)etil] Acil(Aril)tiocarbammati, inibitori non nucleosidici della trascrittasi inversa di HIV-1 61
Molecular docking of the Escherichia coli PTS system 58
One-pot Stereoselective Synthesis of Knoevenageltype Derivatives Via Condensation of N-Methyleniminium Salts of Ethylenethiourea and Ethyleneurea with Active Methylene Reagents. 58
Non-PAMAM amino acids-modified dendrimers nanoparticles for enhancing water-solubility of insoluble bioactive molecules: our state of the art 58
Synthesis of indole imminun salts as key-intermediates in a convergent multi-step one-pot stereoselective synthesis of new potent antiproliferative Knoevenagel-type agent 57
Sintesi parallela one-pot di disolfuri dimeri di tiocarbammati, una nuova potente classe di inibitori non nucleosidici della transcrittasi inversa 57
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Virtual screening and structure based drug design of new Fes/Fps kinase domain inhibitors. 55
Parallel synthesis of O-phenoxyethyl and O-adamantyl N-acyl thiocarbamates endowed with antiproliferative activity. 54
Anthrax toxin: structure-function relationships 54
Escherichia coli GlpE is a prototype sulfurtransferase for the single-domain rhodanese homology superfamily 53
Capitolo 18 - Farmaci attivi sul sistema renale 49
Studies on the catalitic activity of Azotobacter vinelandii rhodanese 49
Modulazioni Strutturali in O-[2-(N-Ftalimmido)etil] Acil(Aril)Tiocarbammati, Inibitori Non-Nucleosidici della Transcrittasi Inversa di HIV-1 48
Synthesis and anti-HIV-1 activity of thiocarbamates, isosteres of PETT derivatives 47
SseA, a 3-mercaptopyruvate sulfurtransferase from Escherichia coli: crystallization and preliminary crystallographic data 47
Exploring the binding features of rimonabant analogues and acyclic CB1 antagonists: docking studies and 3D-QSAR analysis 46
Capitolo 19 - Agenti cardiovascolari 45
Studi Cristallografici di Complessi tra Transcrittasi Inversa di HIV-1 e Derivati Tiocarbammici a Scheletro Ftalimmidico, Inibitori Non Nucleosidici Correlati ai Derivati PETT. 42
Reattivita' di accettori di Michael atipici con nucleofili azotati 42
Sintesi di Esteri Tienopirimidinici ad Attività Antiproliferativa 41
Progettazione e Sintesi di Nuovi O-[2-(N-Ftalimmido)etil]-N-(4-Cloro- e 4-Metil-Fenil)-N-Aciltiocarbammati, Inibitori Non Nucleosidici della Trancrittasi Inversa del Virus HIV-1 Attivi a Concentrazioni Nanomolari 41
Capitolo 14 - Anticonvulsivanti 41
Modulazioni Strutturali del Sistema Ftalimmidico di N-Aril Tiocarbammati, Inibitori Non-Nucleosidici della Transcrittasi Inversa di HIV-1 40
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Assessing the chemical cross-reaction from cefixime and some non-steroidal anti-inflammatory agents in a soluble formulation 39
Sintesi Convergente “One-Pot” di Aciltiocarbammati ad Attività Antiproliferativa 38
Characterization of water soluble dendrimer formulations of an insoluble thiocarbamate derivative with moderate anti HIV-1 activity: an overview 38
Non-receptor tyrosine kinase Fes as a target in oncology 37
Computational approaches for the design and chemical synthesis of novel F508del correctors in the treatment of cystic fibrosis 36
Sintesi di tiocarbammati bioisosteri della trovirdina con attivita' antiretrovirale 33
Synthesis and prelimary docking studies of new colchicine-benzotriazole hybrid compounds 33
Synthesis and SAR studies of novel merbarone analogues 33
Hydrophilic and amphiphilic water-soluble dendrimer formulations of a not-soluble thiocarbamate derivative with moderate anti HIV activity for biomedical applications. 29
BRD9-targeting PROTACs: design, synthesis and biological evaluation 28
Pharmacophore and pharmacokinetic filtering tools guiding for the design and synthesis of novel thiazole-containing and VX-809 hybrid derivatives as F508del correctors. 27
Effetti della orto, meta e para Sostituzione della Porzione N-Fenilica di O-(2-Ftalimmidoetil)-2-tenoilcarbammati sull' Attività anti-HIV-1 26
Bicyclic basic merbarone analogues as antiproliferative agents 24
Preparation and characterization of water-soluble, not PAMAM-structured dendrimer prodrugs of an anti-HIV-1 O-TC derivative for in vivo and clinical applications. 22
Synthesis and biological evaluation of new pyrazole carbohydrazides as antiproliferative and antioxidant agents. 21
Valorization and Potential Antimicrobial Use of Olive Mill Wastewater (OMW) from Italian Olive Oil Production 19
One-Pot Synthesis and Antiproliferative Activity of Highly Functionalized Pyrazole Derivatives 18
Btk inhibitors: a medicinal chemistry and drug delivery perspective 18
HIGHLY-FUNCTIONALIZED AMINO PYRAZOLES AS ANTIOXIDANT AGENTS: A PRELIMINARY SYNTHETIC ACCESSIBILITY STUDY 17
Computational studies of the binding mode and 3D-QSAR analyses of symmetric formimidoester disulfides: a new class of non-nucleoside HIV-1 reverse transcriptase inhibitors 15
Totale 6799
Categoria #
all - tutte 11026
article - articoli 6788
book - libri 0
conference - conferenze 3693
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 545
Totale 22052


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2017/2018748 0000 0506 9148 74848
2018/2019591 410246 982 1613 888184147
2019/20202200 10050115107 201231 324117 17640628885
2020/2021467 36343133 3248 2145 49564141
2021/20221196 309279118 3571 78317 559776148
2022/2023768 14111913177 24969 00 0000
Totale 7047