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Tesi di dottorato 2045

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THE NEW DIGITAL AVANT-GARDE CURRENT POSTCOLONIAL MIGRATION NARRATIVES

This work is a study of current migration narratives within the disciplines of Anglophone Postcolonial Literature and Digital Humanities. Global culture, the proliferation and pervasiveness of telecommunication technologies and new media, particularly the Internet, have substantially affected the act of narrating. The replacement of traditional written language as the primary means of conveying narrative and storytelling is a distinctive feature in the examples selected for this research. The...

CLASSIFYING IMMUNE DISPOSITION IN NEUROBLASTOMA USING OPTICAL MICROSCOPY TECHNIQUES AND GENE EXPRESSION PROFILING

Neuroblastoma, the most common extracranial solid tumor in children, is a complex and challenging disease. The recent removal of the IVS (4S) category from clinical practice has left a crucial gap in our understanding of this unique subtype, particularly its remarkable ability to regress spontaneously. This thesis embarks on a journey to uncover the secrets of the tumor microenvironment (TME) in Neuroblastoma, using cutting-edge spatial immunofluorescence and RNA sequencing to explore how the...

Biological modifications of the immune response to COVID-19 vaccine in patients treated with anti-CD20 agents and immune-checkpoint inhibitors.

Investigating the impact of immune-modulating therapies on mRNA vaccine efficacy transcends the immediate context of the COVID-19 pandemic. This thesis focuses on the differential immune responses to the third dose of COVID-19 mRNA vaccine among healthy vol- unteers, cancer patients treated with immune-checkpoint inhibitors (ICIs), and those treated with the anti-CD20 antibody rituximab. Utilizing RNA sequencing, serology, and interferon-gamma release as- sessment, we charted the temporal dyn...

IN-HOSPITAL ACUTE KIDNEY INJURY: STUDY OF PREVALENCE, SEX DIFFERECES AND MORTALITY.

Background: Hospital Acute kidney injury (H-AKI) is a complex entity associated with an increased risk of complications and mortality. Its occurrence and outcome are influenced by several patient and organizational-related factors. Due to the biological and genetic differences, sex may greatly influence the kidney function. However, Italian epidemiological data on H-AKI incidence and prognosis are scarce. Moreover, the impact of sex on H-AKI risk and related consequences is still unclear. ...

Knowledge Transferability for Data-Efficient Deep Learning

Deep Learning has demonstrated remarkable progress in various Computer Vision tasks. However, its effectiveness often relies on the availability of large, well-annotated datasets. In many practical scenarios, there is often limited availability of such data. Furthermore, collecting or labeling more samples that align with the post-deployment environment can sometimes be challenging or impossible, resulting in reduced and sub-optimal performance. Transfer Learning (TL) emerges as a promising s...

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