Magnetic iron oxide nanoparticles (Fe3O4-MNPs) have been a topic of great interest given their potential use for magnetic hyperthermia treatment (MHT). This cancer therapy is based on the heat released by MNPs when exposed to alternating magnetic fields (AMFs). The performance of MNPs in MHT is evaluated by measuring the specific absorption rate (SAR), which is related to MNP’s heat dissipation under an AMFs. The SAR value strongly depends on the design of MNPs (i.e., shape, size distribution, crystallinity, saturation magnetization(Ms)). Indeed, several synthetic routes have been developed to produce MNPs in order to increase their heating and magnetic performances. Among them, thermal decomposition is a common method used to produce monodisperse MNPs showing high Ms, maintaining good control over shape and composition. However, it is limited by the amount of final product which is in the mg-scale per synthesis, very far from clinical need. In this work, to scale up the production of MNPs to gram-scale, we exploit the solvothermal method. The synthesis solution is composed by an alcohol solvent, carboxylic acid, primary amine, iron precursor, and shape-directing agent. In particular, we found out that benzaldehyde and its derivatives can promote the formation of cubic-like nanoparticles; instead, by using aliphatic aldehydes, spherical and hexagonal shapes are formed. Moreover, the replacement of the primary amine with secondary or tertiary amines favors the formation of stars-like shape. The method developed is simple and straightforward, giving the possibility to carry out multiple syntheses obtaining MNPs in gram-scale amounts with benchmark MHT performance.
Scale-up Syntheses of Magnetic Ferrite Nanoparticles with Different Shapes and Enhanced Performance for Magnetic Hyperthermia Applications
Giusy Maria Rita Rizzo;
2023-01-01
Abstract
Magnetic iron oxide nanoparticles (Fe3O4-MNPs) have been a topic of great interest given their potential use for magnetic hyperthermia treatment (MHT). This cancer therapy is based on the heat released by MNPs when exposed to alternating magnetic fields (AMFs). The performance of MNPs in MHT is evaluated by measuring the specific absorption rate (SAR), which is related to MNP’s heat dissipation under an AMFs. The SAR value strongly depends on the design of MNPs (i.e., shape, size distribution, crystallinity, saturation magnetization(Ms)). Indeed, several synthetic routes have been developed to produce MNPs in order to increase their heating and magnetic performances. Among them, thermal decomposition is a common method used to produce monodisperse MNPs showing high Ms, maintaining good control over shape and composition. However, it is limited by the amount of final product which is in the mg-scale per synthesis, very far from clinical need. In this work, to scale up the production of MNPs to gram-scale, we exploit the solvothermal method. The synthesis solution is composed by an alcohol solvent, carboxylic acid, primary amine, iron precursor, and shape-directing agent. In particular, we found out that benzaldehyde and its derivatives can promote the formation of cubic-like nanoparticles; instead, by using aliphatic aldehydes, spherical and hexagonal shapes are formed. Moreover, the replacement of the primary amine with secondary or tertiary amines favors the formation of stars-like shape. The method developed is simple and straightforward, giving the possibility to carry out multiple syntheses obtaining MNPs in gram-scale amounts with benchmark MHT performance.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
