Multicomponent reactions can be positively affected by the use of continuous flow approaches in terms of yield, selectivity, reaction time, real-time monitoring. Moreover, syntheses can be performed in a telescoped manner, with addition of components at different stages. Thus, reactions that by definition are not multicomponent in batch, can be considered so in flow. This chapter is focused on the different approaches that can be used to perform heterocycle multicomponent syntheses in continuous flow, and selected examples taken from the recent literature are used to highlight the advantages over batch synthesis.
The Use of Flow Chemistry in the Multicomponent Synthesis of Heterocycles
Lambruschini C.;Moni L.;Basso A.
2021-01-01
Abstract
Multicomponent reactions can be positively affected by the use of continuous flow approaches in terms of yield, selectivity, reaction time, real-time monitoring. Moreover, syntheses can be performed in a telescoped manner, with addition of components at different stages. Thus, reactions that by definition are not multicomponent in batch, can be considered so in flow. This chapter is focused on the different approaches that can be used to perform heterocycle multicomponent syntheses in continuous flow, and selected examples taken from the recent literature are used to highlight the advantages over batch synthesis.
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