Epigenetic Regulation in Myelodysplastic Syndrome as A Consequence of A MicroRNA Dysregulation

The myelodysplastic syndromes are a group of diseases characterized by impairment in hemopoiesis and variable tendency to progress to acute myeloid leukemia. Recent data regarding the MDS pathogenesis highlight alterations in several compartments of DNA replication, cell cycle control, and gene expression machinery. As previously reported, miRNA families are involved in MDS pathogenesis. Also, different miRNAs have been characterized in AML and MDS and allow the identification of prognostic risk categories independent from the revised international prognostic scoring system (R-IPSS). Herein we report the results and the possible scenarios regarding pathogenesis and disease progression secondary to the evidence of considerable gene network derangement following miRNA evaluation in a cohort of patients.