TOMATI, VALERIA
TOMATI, VALERIA
100009 - Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili
Clinical Consequences and Functional Impact of the Rare S737F CFTR Variant and Its Responsiveness to CFTR Modulators
2023-01-01 Terlizzi, V.; Pesce, E.; Capurro, V.; Tomati, V.; Lena, M.; Pastorino, C.; Bocciardi, R.; Zara, F.; Centrone, C.; Taccetti, G.; Castellani, C.; Pedemonte, N.
De novo variants in DENND5B cause a neurodevelopmental disorder
2024-01-01 Scala, Marcello; Tomati, Valeria; Ferla, Matteo; Lena, Mariateresa; Cohen, Julie S; Fatemi, Ali; Brokamp, Elly; Bican, Anna; Phillips, John A; Koziura, Mary E; Nicouleau, Michael; Rio, Marlene; Siquier, Karine; Boddaert, Nathalie; Musante, Ilaria; Tamburro, Serena; Baldassari, Simona; Iacomino, Michele; Scudieri, Paolo; Rosenfeld, Jill A; Bellus, Gary; Reed, Sara; Al Saif, Hind; Russo, Rossana Sanchez; Walsh, Matthew B; Cantagrel, Vincent; Crunk, Amy; Gustincich, Stefano; Ruggiero, Sarah M; Fitzgerald, Mark P; Helbig, Ingo; Striano, Pasquale; Severino, Mariasavina; Salpietro, Vincenzo; Pedemonte, Nicoletta; Zara, Federico
Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel
2020-01-01 Pedemonte, N.; Bertozzi, F.; Caci, E.; Sorana, F.; Fruscia, P. D.; Tomati, V.; Ferrera, L.; Rodriguez-Gimeno, A.; Berti, F.; Pesce, E.; Sondo, E.; Gianotti, A.; Scudieri, P.; Bandiera, T.; Galietta, L. J. V.
Discovery of novel VX-809 hybrid derivatives as F508del-CFTR correctors by molecular modeling, chemical synthesis and biological assays
2020-01-01 Parodi, A.; Righetti, G.; Pesce, E.; Salis, A.; Tasso, B.; Urbinati, C.; Tomati, V.; Damonte, G.; Rusnati, M.; Pedemonte, N.; Cichero, E.; Millo, E.
High-throughput screening identifies FAU protein as a regulator of mutant cystic fibrosis transmembrane conductance regulator channel
2018-01-01 Tomati, V.; Pesce, E.; Caci, E.; Sondo, E.; Scudieri, P.; Marini, M.; Amato, F.; Castaldo, G.; Ravazzolo, R.; Galietta, L. J. V.; Pedemonte, N.
Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays
2022-01-01 Parodi, Alice; Righetti, Giada; Pesce, Emanuela; Salis, Annalisa; Tomati, Valeria; Pastorino, Cristina; Tasso, Bruno; Benvenuti, Mirko; Damonte, Gianluca; Pedemonte, Nicoletta; Cichero, Elena; Millo, Enrico
Partial rescue of f508del-cftr stability and trafficking defects by double corrector treatment
2021-01-01 Capurro, V.; Tomati, V.; Sondo, E.; Renda, M.; Borrelli, A.; Pastorino, C.; Guidone, D.; Venturini, A.; Giraudo, A.; Bertozzi, S. M.; Musante, I.; Bertozzi, F.; Bandiera, T.; Zara, F.; Galietta, L. J. V.; Pedemonte, N.
Patient's dermal fibroblasts as disease markers for visceral myopathy
2023-01-01 Viti, Federica; Pramotton, Francesca Micaela; Martufi, Michela; Magrassi, Raffaella; Pedemonte, Nicoletta; Nizzari, Mario; Zanacchi, Francesca Cella; De Michele, Benedetta; Alampi, Manuela; Zambito, Martina; Santamaria, Giuseppe; Bajetto, Adriana; Sardar, Sabah; Tomati, Valeria; Gandullia, Paolo; Giampietro, Costanza; Florio, Tullio; Beltrame, Francesco; Vassalli, Massimo; Ceccherini, Isabella
Rescue by elexacaftor-tezacaftor-ivacaftor of the G1244E cystic fibrosis mutation's stability and gating defects are dependent on cell background
2023-01-01 Tomati, Valeria; Costa, Stefano; Capurro, Valeria; Pesce, Emanuela; Pastorino, Cristina; Lena, Mariateresa; Sondo, Elvira; Di Duca, Marco; Cresta, Federico; Cristadoro, Simona; Zara, Federico; Galietta, Luis J V; Bocciardi, Renata; Castellani, Carlo; Lucanto, Maria Cristina; Pedemonte, Nicoletta
Targeting of Ubiquitin E3 Ligase RNF5 as a Novel Therapeutic Strategy in Neuroectodermal Tumors
2022-01-01 Principi, E.; Sondo, E.; Bianchi, G.; Ravera, S.; Morini, M.; Tomati, V.; Pastorino, C.; Zara, F.; Bruno, C.; Eva, A.; Pedemonte, N.; Raffaghello, L.
The Autophagy Inhibitor Spautin-1 Antagonizes Rescue of Mutant CFTR Through an Autophagy-Independent and USP13-Mediated Mechanism
2018-01-01 Pesce, Emanuela; Sondo, Elvira; Ferrera, Loretta; Tomati, Valeria; Caci, Emanuela; Scudieri, Paolo; Musante, Ilaria; Renda, Mario; Baatallah, Nesrine; Servel, Nathalie; Hinzpeter, Alexandre; di Bernardo, Diego; Pedemonte, Nicoletta; Galietta, Luis J V
The L467F-F508del Complex Allele Hampers Pharmacological Rescue of Mutant CFTR by Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Patients: The Value of the Ex Vivo Nasal Epithelial Model to Address Non-Responders to CFTR-Modulating Drugs
2022-01-01 Sondo, E.; Cresta, F.; Pastorino, C.; Tomati, V.; Capurro, V.; Pesce, E.; Lena, M.; Iacomino, M.; Baffico, A. M.; Coviello, D.; Bandiera, T.; Zara, F.; Galietta, L. J. V.; Bocciardi, R.; Castellani, C.; Pedemonte, N.
Two CFTR mutations within codon 970 differently impact on the chloride channel functionality
2019-01-01 Amato, F.; Scudieri, P.; Musante, I.; Tomati, V.; Caci, E.; Comegna, M.; Maietta, S.; Manzoni, F.; Di Lullo, A. M.; De Wachter, E.; Vanderhelst, E.; Terlizzi, V.; Braggion, C.; Castaldo, G.; Galietta, L. J. V.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Clinical Consequences and Functional Impact of the Rare S737F CFTR Variant and Its Responsiveness to CFTR Modulators | 1-gen-2023 | Terlizzi, V.; Pesce, E.; Capurro, V.; Tomati, V.; Lena, M.; Pastorino, C.; Bocciardi, R.; Zara, F.; Centrone, C.; Taccetti, G.; Castellani, C.; Pedemonte, N. | |
| De novo variants in DENND5B cause a neurodevelopmental disorder | 1-gen-2024 | Scala, Marcello; Tomati, Valeria; Ferla, Matteo; Lena, Mariateresa; Cohen, Julie S; Fatemi, Ali; Brokamp, Elly; Bican, Anna; Phillips, John A; Koziura, Mary E; Nicouleau, Michael; Rio, Marlene; Siquier, Karine; Boddaert, Nathalie; Musante, Ilaria; Tamburro, Serena; Baldassari, Simona; Iacomino, Michele; Scudieri, Paolo; Rosenfeld, Jill A; Bellus, Gary; Reed, Sara; Al Saif, Hind; Russo, Rossana Sanchez; Walsh, Matthew B; Cantagrel, Vincent; Crunk, Amy; Gustincich, Stefano; Ruggiero, Sarah M; Fitzgerald, Mark P; Helbig, Ingo; Striano, Pasquale; Severino, Mariasavina; Salpietro, Vincenzo; Pedemonte, Nicoletta; Zara, Federico | |
| Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel | 1-gen-2020 | Pedemonte, N.; Bertozzi, F.; Caci, E.; Sorana, F.; Fruscia, P. D.; Tomati, V.; Ferrera, L.; Rodriguez-Gimeno, A.; Berti, F.; Pesce, E.; Sondo, E.; Gianotti, A.; Scudieri, P.; Bandiera, T.; Galietta, L. J. V. | |
| Discovery of novel VX-809 hybrid derivatives as F508del-CFTR correctors by molecular modeling, chemical synthesis and biological assays | 1-gen-2020 | Parodi, A.; Righetti, G.; Pesce, E.; Salis, A.; Tasso, B.; Urbinati, C.; Tomati, V.; Damonte, G.; Rusnati, M.; Pedemonte, N.; Cichero, E.; Millo, E. | |
| High-throughput screening identifies FAU protein as a regulator of mutant cystic fibrosis transmembrane conductance regulator channel | 1-gen-2018 | Tomati, V.; Pesce, E.; Caci, E.; Sondo, E.; Scudieri, P.; Marini, M.; Amato, F.; Castaldo, G.; Ravazzolo, R.; Galietta, L. J. V.; Pedemonte, N. | |
| Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays | 1-gen-2022 | Parodi, Alice; Righetti, Giada; Pesce, Emanuela; Salis, Annalisa; Tomati, Valeria; Pastorino, Cristina; Tasso, Bruno; Benvenuti, Mirko; Damonte, Gianluca; Pedemonte, Nicoletta; Cichero, Elena; Millo, Enrico | |
| Partial rescue of f508del-cftr stability and trafficking defects by double corrector treatment | 1-gen-2021 | Capurro, V.; Tomati, V.; Sondo, E.; Renda, M.; Borrelli, A.; Pastorino, C.; Guidone, D.; Venturini, A.; Giraudo, A.; Bertozzi, S. M.; Musante, I.; Bertozzi, F.; Bandiera, T.; Zara, F.; Galietta, L. J. V.; Pedemonte, N. | |
| Patient's dermal fibroblasts as disease markers for visceral myopathy | 1-gen-2023 | Viti, Federica; Pramotton, Francesca Micaela; Martufi, Michela; Magrassi, Raffaella; Pedemonte, Nicoletta; Nizzari, Mario; Zanacchi, Francesca Cella; De Michele, Benedetta; Alampi, Manuela; Zambito, Martina; Santamaria, Giuseppe; Bajetto, Adriana; Sardar, Sabah; Tomati, Valeria; Gandullia, Paolo; Giampietro, Costanza; Florio, Tullio; Beltrame, Francesco; Vassalli, Massimo; Ceccherini, Isabella | |
| Rescue by elexacaftor-tezacaftor-ivacaftor of the G1244E cystic fibrosis mutation's stability and gating defects are dependent on cell background | 1-gen-2023 | Tomati, Valeria; Costa, Stefano; Capurro, Valeria; Pesce, Emanuela; Pastorino, Cristina; Lena, Mariateresa; Sondo, Elvira; Di Duca, Marco; Cresta, Federico; Cristadoro, Simona; Zara, Federico; Galietta, Luis J V; Bocciardi, Renata; Castellani, Carlo; Lucanto, Maria Cristina; Pedemonte, Nicoletta | |
| Targeting of Ubiquitin E3 Ligase RNF5 as a Novel Therapeutic Strategy in Neuroectodermal Tumors | 1-gen-2022 | Principi, E.; Sondo, E.; Bianchi, G.; Ravera, S.; Morini, M.; Tomati, V.; Pastorino, C.; Zara, F.; Bruno, C.; Eva, A.; Pedemonte, N.; Raffaghello, L. | |
| The Autophagy Inhibitor Spautin-1 Antagonizes Rescue of Mutant CFTR Through an Autophagy-Independent and USP13-Mediated Mechanism | 1-gen-2018 | Pesce, Emanuela; Sondo, Elvira; Ferrera, Loretta; Tomati, Valeria; Caci, Emanuela; Scudieri, Paolo; Musante, Ilaria; Renda, Mario; Baatallah, Nesrine; Servel, Nathalie; Hinzpeter, Alexandre; di Bernardo, Diego; Pedemonte, Nicoletta; Galietta, Luis J V | |
| The L467F-F508del Complex Allele Hampers Pharmacological Rescue of Mutant CFTR by Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Patients: The Value of the Ex Vivo Nasal Epithelial Model to Address Non-Responders to CFTR-Modulating Drugs | 1-gen-2022 | Sondo, E.; Cresta, F.; Pastorino, C.; Tomati, V.; Capurro, V.; Pesce, E.; Lena, M.; Iacomino, M.; Baffico, A. M.; Coviello, D.; Bandiera, T.; Zara, F.; Galietta, L. J. V.; Bocciardi, R.; Castellani, C.; Pedemonte, N. | |
| Two CFTR mutations within codon 970 differently impact on the chloride channel functionality | 1-gen-2019 | Amato, F.; Scudieri, P.; Musante, I.; Tomati, V.; Caci, E.; Comegna, M.; Maietta, S.; Manzoni, F.; Di Lullo, A. M.; De Wachter, E.; Vanderhelst, E.; Terlizzi, V.; Braggion, C.; Castaldo, G.; Galietta, L. J. V. |