Sfoglia per Autore
Homology modeling, docking studies and molecular dynamic simulations using GPU architecture to probe the type-11 Phosphodiesterase (PDE11) catalytic site: a computational approach for the rational design of selective inhibitors.
2013-01-01 Cichero, Elena; D’Ursi, P.; Moscatelli, M.; Bruno, Olga; Orro, A.; Rotolo, Chiara; Milanesi, L.; Fossa, Paola
Further Insights Into the Pharmacology of the Human Trace Amine-Associated Receptors: Discovery of Novel Ligands for TAAR1 by a Virtual Screening Approach.
2014-01-01 Cichero, Elena; Espinoza, S; Franchini, S; Guariento, S; Brasili, L; Gainetdinov, Rr; Fossa, Paola
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors.
2014-01-01 Franchini, S; Battisti, Um; Baraldi, A; Prandi, A; Fossa, Paola; Cichero, Elena; Tait, A; Sorbi, C; Marucci, G; Cilia, A; Pirona, L; Brasili, L.
Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1 and 5-HT1A receptor ligand: an in vitro and computational study
2015-01-01 Franchini, Silvia; Baraldi, Annamaria; Sorbi, Claudia; Pellati, Federica; Cichero, Elena; Battisti, Umbero M.; Angeli, Piero; Cilia, Antonio; Brasili, Livio
Ligand-based homology modelling of the human CB2 receptor SR144528 antagonist binding site: a computational approach to explore the 1,5-diaryl pyrazole scaffold
2015-01-01 Cichero, Elena; Menozzi, Giulia; Guariento, Sara; Fossa, Paola
In silico evaluation of human small heat shock protein HSP27: Homology modeling, mutation analyses and docking studies
2015-01-01 Fossa, Paola; Cichero, Elena
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis
2015-01-01 Pesce, Emanuela; Bellotti, Marta; Liessi, Nara; Guariento, Sara; Damonte, Gianluca; Cichero, Elena; Galatini, Andrea; Salis, Annalisa; Gianotti, Ambra; Pedemonte, Nicoletta; Zegarra Moran, Olga; Fossa, Paola; Galietta, Luis J. V; Millo, Enrico
Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists
2015-01-01 Chiellini, Grazia; Nesi, Giulia; Digiacomo, Maria; Malvasi, Rossella; Espinoza, Stefano; Sabatini, Martina; Frascarelli, Sabina; Laurino, Annunziatina; Cichero, Elena; Macchia, Marco; Gainetdinov, Raul R.; Fossa, Paola; Raimondi, Laura; Zucchi, Riccardo; Rapposelli, Simona
Fight against H1N1 Influenza A Virus: Recent Insights towards the Development of Druggable Compounds
2016-01-01 Tonelli, Michele; Cichero, Elena
Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors
2016-01-01 Cichero, Elena; Brullo, Chiara; Bruno, Olga; Fossa, Paola
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment
2016-01-01 Brullo, Chiara; Ricciarelli, Roberta; Prickaerts, Jos; Arancio, Ottavio; Massa, Matteo; Rotolo, Chiara; Romussi, Alessia; Rebosio, Claudia; Marengo, Barbara; Pronzato, MARIA ADELAIDE; van Hagen, Britt T. J.; van Goethem, Nick P.; D'Ursi, Pasqualina; Orro, Alessandro; Milanesi, Luciano; Guariento, Sara; Cichero, Elena; Fossa, Paola; Fedele, Ernesto; Bruno, Olga
Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics
2016-01-01 D'Ursi, Pasqualina; Guariento, Sara; Trombetti, Gabriele; Orro, Alessandro; Cichero, Elena; Milanesi, Luciano; Fossa, Paola; Bruno, Olga
New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies
2016-01-01 Guariento, Sara; Bruno, Olga; Fossa, Paola; Cichero, Elena
Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1
2016-01-01 Capponi, Simona; Geuens, Thomas; Geroldi, Alessandro; Origone, Paola; Verdiani, Simonetta; Cichero, Elena; Adriaenssens, Elias; De Winter, Vicky; BANDETTINI DI POGGIO, MONICA LAURA; Barberis, Marco; Chiò, Adriano; Fossa, Paola; Mandich, Paola; Bellone, Emilia; Timmerman, Vincent
Impaired Chaperone Activity of Human Heat Shock Protein Hsp27 Site-Specifically Modified with Argpyrimidine
2016-01-01 Matveenko, Maria; Cichero, Elena; Fossa, Paola; Becker, Christian F. W.
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties.
2016-01-01 Deiana, V.; Gómez Cañas, M.; Pazos, M. R.; Fernández Ruiz, J.; Asproni, B.; Cichero, Elena; Fossa, Paola; Muñoz, E.; Deligia, F.; Murineddu, G.; García Arencibia, M.; Pinna, G. A.
Hit-to-lead optimization of mouse Trace Amine Associated Receptor 1 (mTAAR1) agonists with a diphenylmethane-scaffold: Design, Synthesis, and biological study
2016-01-01 Chiellini, Grazia; Nesi, Giulia; Sestito, Simona; Chiarugi, Sara; Runfola, Massimiliano; Espinoza, Stefano; Sabatini, Martina; Bellusci, Lorenza; Laurino, Annunziatina; Cichero, Elena; Gainetdinov, Raul R; Fossa, Paola; Raimondi, Laura; Zucchi, Riccardo; Rapposelli, Simona
Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB2receptor antagonists/inverse agonists
2016-01-01 Dore, Antonio; Asproni, Battistina; Scampuddu, Alessia; Gessi, Stefania; Murineddu, Gabriele; Cichero, Elena; Fossa, Paola; Merighi, Stefania; Bencivenni, Serena; Pinna, Gérard A.
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives
2016-01-01 Franchini, Silvia; Battisti, Umberto Maria; Prandi, Adolfo; Tait, Annalisa; Borsari, Chiara; Cichero, Elena; Fossa, Paola; Cilia, Antonio; Prezzavento, Orazio; Ronsisvalle, Simone; Aricò, Giuseppina; Parenti, Carmela; Brasili, Livio
Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles
2017-01-01 Cichero, Elena; Tonelli, Michele; Novelli, Federica; Tasso, Bruno; Delogu, I; Loddo, R.; Bruno, Olga; Fossa, Paola
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Homology modeling, docking studies and molecular dynamic simulations using GPU architecture to probe the type-11 Phosphodiesterase (PDE11) catalytic site: a computational approach for the rational design of selective inhibitors. | 1-gen-2013 | Cichero, Elena; D’Ursi, P.; Moscatelli, M.; Bruno, Olga; Orro, A.; Rotolo, Chiara; Milanesi, L.; Fossa, Paola | |
| Further Insights Into the Pharmacology of the Human Trace Amine-Associated Receptors: Discovery of Novel Ligands for TAAR1 by a Virtual Screening Approach. | 1-gen-2014 | Cichero, Elena; Espinoza, S; Franchini, S; Guariento, S; Brasili, L; Gainetdinov, Rr; Fossa, Paola | |
| Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α<alpha>1 and 5-HT1A receptors. | 1-gen-2014 | Franchini, S; Battisti, Um; Baraldi, A; Prandi, A; Fossa, Paola; Cichero, Elena; Tait, A; Sorbi, C; Marucci, G; Cilia, A; Pirona, L; Brasili, L. | |
| Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1 and 5-HT1A receptor ligand: an in vitro and computational study | 1-gen-2015 | Franchini, Silvia; Baraldi, Annamaria; Sorbi, Claudia; Pellati, Federica; Cichero, Elena; Battisti, Umbero M.; Angeli, Piero; Cilia, Antonio; Brasili, Livio | |
| Ligand-based homology modelling of the human CB2 receptor SR144528 antagonist binding site: a computational approach to explore the 1,5-diaryl pyrazole scaffold | 1-gen-2015 | Cichero, Elena; Menozzi, Giulia; Guariento, Sara; Fossa, Paola | |
| In silico evaluation of human small heat shock protein HSP27: Homology modeling, mutation analyses and docking studies | 1-gen-2015 | Fossa, Paola; Cichero, Elena | |
| Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis | 1-gen-2015 | Pesce, Emanuela; Bellotti, Marta; Liessi, Nara; Guariento, Sara; Damonte, Gianluca; Cichero, Elena; Galatini, Andrea; Salis, Annalisa; Gianotti, Ambra; Pedemonte, Nicoletta; Zegarra Moran, Olga; Fossa, Paola; Galietta, Luis J. V; Millo, Enrico | |
| Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists | 1-gen-2015 | Chiellini, Grazia; Nesi, Giulia; Digiacomo, Maria; Malvasi, Rossella; Espinoza, Stefano; Sabatini, Martina; Frascarelli, Sabina; Laurino, Annunziatina; Cichero, Elena; Macchia, Marco; Gainetdinov, Raul R.; Fossa, Paola; Raimondi, Laura; Zucchi, Riccardo; Rapposelli, Simona | |
| Fight against H1N1 Influenza A Virus: Recent Insights towards the Development of Druggable Compounds | 1-gen-2016 | Tonelli, Michele; Cichero, Elena | |
| Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors | 1-gen-2016 | Cichero, Elena; Brullo, Chiara; Bruno, Olga; Fossa, Paola | |
| New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment | 1-gen-2016 | Brullo, Chiara; Ricciarelli, Roberta; Prickaerts, Jos; Arancio, Ottavio; Massa, Matteo; Rotolo, Chiara; Romussi, Alessia; Rebosio, Claudia; Marengo, Barbara; Pronzato, MARIA ADELAIDE; van Hagen, Britt T. J.; van Goethem, Nick P.; D'Ursi, Pasqualina; Orro, Alessandro; Milanesi, Luciano; Guariento, Sara; Cichero, Elena; Fossa, Paola; Fedele, Ernesto; Bruno, Olga | |
| Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics | 1-gen-2016 | D'Ursi, Pasqualina; Guariento, Sara; Trombetti, Gabriele; Orro, Alessandro; Cichero, Elena; Milanesi, Luciano; Fossa, Paola; Bruno, Olga | |
| New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies | 1-gen-2016 | Guariento, Sara; Bruno, Olga; Fossa, Paola; Cichero, Elena | |
| Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1 | 1-gen-2016 | Capponi, Simona; Geuens, Thomas; Geroldi, Alessandro; Origone, Paola; Verdiani, Simonetta; Cichero, Elena; Adriaenssens, Elias; De Winter, Vicky; BANDETTINI DI POGGIO, MONICA LAURA; Barberis, Marco; Chiò, Adriano; Fossa, Paola; Mandich, Paola; Bellone, Emilia; Timmerman, Vincent | |
| Impaired Chaperone Activity of Human Heat Shock Protein Hsp27 Site-Specifically Modified with Argpyrimidine | 1-gen-2016 | Matveenko, Maria; Cichero, Elena; Fossa, Paola; Becker, Christian F. W. | |
| Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. | 1-gen-2016 | Deiana, V.; Gómez Cañas, M.; Pazos, M. R.; Fernández Ruiz, J.; Asproni, B.; Cichero, Elena; Fossa, Paola; Muñoz, E.; Deligia, F.; Murineddu, G.; García Arencibia, M.; Pinna, G. A. | |
| Hit-to-lead optimization of mouse Trace Amine Associated Receptor 1 (mTAAR1) agonists with a diphenylmethane-scaffold: Design, Synthesis, and biological study | 1-gen-2016 | Chiellini, Grazia; Nesi, Giulia; Sestito, Simona; Chiarugi, Sara; Runfola, Massimiliano; Espinoza, Stefano; Sabatini, Martina; Bellusci, Lorenza; Laurino, Annunziatina; Cichero, Elena; Gainetdinov, Raul R; Fossa, Paola; Raimondi, Laura; Zucchi, Riccardo; Rapposelli, Simona | |
| Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB2receptor antagonists/inverse agonists | 1-gen-2016 | Dore, Antonio; Asproni, Battistina; Scampuddu, Alessia; Gessi, Stefania; Murineddu, Gabriele; Cichero, Elena; Fossa, Paola; Merighi, Stefania; Bencivenni, Serena; Pinna, Gérard A. | |
| Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives | 1-gen-2016 | Franchini, Silvia; Battisti, Umberto Maria; Prandi, Adolfo; Tait, Annalisa; Borsari, Chiara; Cichero, Elena; Fossa, Paola; Cilia, Antonio; Prezzavento, Orazio; Ronsisvalle, Simone; Aricò, Giuseppina; Parenti, Carmela; Brasili, Livio | |
| Benzimidazole-based derivatives as privileged scaffold developed for the treatment of the RSV infection: a computational study exploring the potency and cytotoxicity profiles | 1-gen-2017 | Cichero, Elena; Tonelli, Michele; Novelli, Federica; Tasso, Bruno; Delogu, I; Loddo, R.; Bruno, Olga; Fossa, Paola |
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