By connecting a synthetic scaffold and a natural shell of Gallic acid: an innovative double-acting antioxidant device to figh «oxidative stress».

Oxidative stress (OS) is involved in the onset and developing of most degenerative diseases hard to fight with exsisting synthetic drugs without adverse side effects. Gallic acid (GA) (Figure 1), a natural triphenolic acid present in several plants, fruits and common foodstuffs, is provided both with the basic nutritional values and with several extra health benefits such as a remarkable antioxidant power. GA exhibited abilities in protecting cells from OS via a number of pathways without triggering unpleasant side effects.1 GA several potentials could be exploited both in industry and in medicine but unfortunately its clinical application is limited by its pharmacokinetic drawbacks, poor bioavailability, slow GIT absorption, fast metabolism and short half-life. Dendrimer nanoparticles, thanks to their nonpareil physicochemical properties are extensively exploited in nanomedicine to control molecular weight, hydrophilicity, solubility,2-4 bioavailability and pharmacokinetic behaviour of drugs as well as to protect them from early degradation or fast metabolism. With the aim at minimizing GA's limitations for medical purposes, in this study, a G5 polyester-based dendrimer was prepared and subsequently, it was peripherally further esterified with bioactive GA.