Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p = 0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p = 0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.
Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?
BELVEDERI MURRI, MARTINO;
2016-01-01
Abstract
Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p = 0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p = 0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.File | Dimensione | Formato | |
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2016 Belvederi Murri progesterone psychosis.pdf
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Descrizione: Copyright © 2016 Martino Belvederi Murri et al. This is an open access article distributed under the Creative Commons AttributionLicense, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Martino Belvederi Murri, Flaminia Fanelli, Uberto Pagotto, et al., “Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?,” Schizophrenia Research and Treatment, vol. 2016, Article ID 1942828, 6 pages, 2016. https://doi.org/10.1155/2016/1942828.
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