T1 mapping with cardiovascular magnetic resonance: An emerging clinical biomarker

We thank Ripley and colleagues for their interest in our paper and agree that T1 mapping with CMR is an emerging imaging biomarker that is increasingly being investigated for its potential role in hypertrophic cardiomyopathy and cardiac hypertrophy in general. Convincing data have been published concerning hypertensive heart disease (Hinojar et al., 2015), hypertrophic and dilated cardiomyopathy (Puntmann et al., 2013), transthyretin amyloidosis (Fontana et al., 2014) and Anderson-Fabry disease (Pica et al., 2014). We have not found any specific published data examining the role of T1 mapping in distinguishing ventricular septal bulge in an elderly population from other etiologies of hypertrophy. We therefore decided not to include T1 mapping in our review (Canepa et al., 2016) but concur that this technique may be potentially useful in the evaluation of ventricular septal bulge.