Selective attentional deficit in essential tremor: Evidence from the attention network test

Pauletti, Caterina; Mannarelli, Daniela; De Lucia, Maria Caterina; Locuratolo, Nicoletta; Currà, Antonio; Missori, Paolo; Marinelli, Lucio; Fattapposta, Francesco

doi:10.1016/j.parkreldis.2015.08.035

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Introduction: The traditional view of essential tremor (ET) as a monosymptomatic and benign disorder has been reconsidered after patients with ET have been shown to experience cognitive deficits that are also related to attention. The Attention Network Test (ANT) is a rapid, widely used test to measure the efficiency of three attentional networks, i.e. alerting, orienting and executive, by evaluating reaction times (RTs) in response to visual stimuli. The aim of this study was to investigate attentional functioning in ET patients by means of the ANT. Methods: 21 non-demented patients with ET and 21 age- and sex-matched healthy controls performed the ANT. Results: RT was significantly longer in ET patients than in controls (p < 0.001). Moreover, a significant difference in alerting and executive efficiency (p = 0.003 and p = 0.01 respectively) was found between groups, while the difference in the orienting efficiency only bordered on significance. Conclusion: Our results point to a difficulty in the alerting and executive domains of attention in ET patients, probably owing to a dysfunction in the cerebello-thalamo-cortical loop. These selective attentional deficits are not related to clinical motor symptoms, contributing to shed further light on the clinical picture of ET.

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Titolo:	Selective attentional deficit in essential tremor: Evidence from the attention network test
Autori:	Pauletti, Caterina Mannarelli, Daniela De Lucia, Maria Caterina Locuratolo, Nicoletta Currà, Antonio Missori, Paolo MARINELLI, LUCIO Fattapposta, Francesco mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2015
Rivista:	PARKINSONISM & RELATED DISORDERS
Handle:	http://hdl.handle.net/11567/845919
Appare nelle tipologie:	01.01 - Articolo su rivista

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