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EnglishWe report the finding of late persistent increased putaminal F-3,4-dihydroxyphenylalanine (DOPA) uptake following resection of a high-grade glioma involving the lateral portion of the ipsilateral precentral gyrus. Brain MRI findings were consistent with secondary putaminal degeneration. This F-DOPA PET phenomenon possibly represents elevated presynaptic dopamine function secondary to upregulation of the amino acid decarboxylase (AADC) activity, as a compensatory mechanism in response to cortical injury. In the setting of brain tumor surveillance, focal increased striatal F-DOPA uptake should be carefully interpreted in light of MRI findings and pathological changes related to corticostriatal connections.
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| Titolo: | Late Persistent Increased Putaminal 18F-DOPA Uptake Following Ipsilateral Frontal Resection: Evidence for Corticostriatal Synaptic Plasticity? |
| Autori: | |
| Data di pubblicazione: | 2015 |
| Rivista: | |
| Abstract: | We report the finding of late persistent increased putaminal F-3,4-dihydroxyphenylalanine (DOPA) uptake following resection of a high-grade glioma involving the lateral portion of the ipsilateral precentral gyrus. Brain MRI findings were consistent with secondary putaminal degeneration. This F-DOPA PET phenomenon possibly represents elevated presynaptic dopamine function secondary to upregulation of the amino acid decarboxylase (AADC) activity, as a compensatory mechanism in response to cortical injury. In the setting of brain tumor surveillance, focal increased striatal F-DOPA uptake should be carefully interpreted in light of MRI findings and pathological changes related to corticostriatal connections. |
| Handle: | http://hdl.handle.net/11567/830680 |
| Appare nelle tipologie: | 01.01 - Articolo su rivista |
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