We report the finding of late persistent increased putaminal F-3,4-dihydroxyphenylalanine (DOPA) uptake following resection of a high-grade glioma involving the lateral portion of the ipsilateral precentral gyrus. Brain MRI findings were consistent with secondary putaminal degeneration. This F-DOPA PET phenomenon possibly represents elevated presynaptic dopamine function secondary to upregulation of the amino acid decarboxylase (AADC) activity, as a compensatory mechanism in response to cortical injury. In the setting of brain tumor surveillance, focal increased striatal F-DOPA uptake should be carefully interpreted in light of MRI findings and pathological changes related to corticostriatal connections.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
Titolo: | Late Persistent Increased Putaminal 18F-DOPA Uptake Following Ipsilateral Frontal Resection: Evidence for Corticostriatal Synaptic Plasticity? |
Autori: | |
Data di pubblicazione: | 2015 |
Rivista: | |
Abstract: | We report the finding of late persistent increased putaminal F-3,4-dihydroxyphenylalanine (DOPA) uptake following resection of a high-grade glioma involving the lateral portion of the ipsilateral precentral gyrus. Brain MRI findings were consistent with secondary putaminal degeneration. This F-DOPA PET phenomenon possibly represents elevated presynaptic dopamine function secondary to upregulation of the amino acid decarboxylase (AADC) activity, as a compensatory mechanism in response to cortical injury. In the setting of brain tumor surveillance, focal increased striatal F-DOPA uptake should be carefully interpreted in light of MRI findings and pathological changes related to corticostriatal connections. |
Handle: | http://hdl.handle.net/11567/830680 |
Appare nelle tipologie: | 01.01 - Articolo su rivista |