Presynaptic, release-regulating metabotropic glutamate 2 and 3 (mGlu2/3) autoreceptors exist in central nervous system (CNS). They represent suitable targets for therapeutic approaches to central diseases that are typified by hyperglutamatergicity. The availability of specific ligands able to differentiate between mGlu2 and mGlu3 subunits allows to further characterize these autoreceptors. This study aims at investigating the pharmacological profile of mGlu2/3 receptors in selected CNS regions and at evaluating their functions in mice suffering from experimental autoimmune encephalomyelitis (EAE).
Presynaptic, release-regulating mGlu2-preferring and mGlu3-preferring autoreceptors in CNS: pharmacological profiles and functional roles in demyelinating disease
DI PRISCO, SILVIA;MEREGA, ELISA;BONFIGLIO, TOMMASO;OLIVERO, GUENDALINA;CERVETTO, CHIARA;GRILLI, MASSIMO;USAI, CESARE;MARCHI, MARIO;PITTALUGA, ANNA MARIA
2016-01-01
Abstract
Presynaptic, release-regulating metabotropic glutamate 2 and 3 (mGlu2/3) autoreceptors exist in central nervous system (CNS). They represent suitable targets for therapeutic approaches to central diseases that are typified by hyperglutamatergicity. The availability of specific ligands able to differentiate between mGlu2 and mGlu3 subunits allows to further characterize these autoreceptors. This study aims at investigating the pharmacological profile of mGlu2/3 receptors in selected CNS regions and at evaluating their functions in mice suffering from experimental autoimmune encephalomyelitis (EAE).
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