All possible stereoisomers of triols of general formula 6 (R1 = allyl, R2 = Me or allyl) have been synthesized stereoselectively starting from asymmetrized bis(hydroxymethy1)acetaldehyde (BHYMA*), a novel chiral building block prepared through a chemoenzymatic methodology. This goal was realized through a sequence of protecting group-controlled nucleophilic additions and/or reductions performed on two side arms of this versatile building block.
Highly Versatile Stereoselective Synthesis of All Eight Stereoisomers of Branched-Chain Triols Starting from Asymmetrized Bis(hydroxymethyl)acetaldehydes (BHYMA)
BANFI, LUCA;GUANTI, GIUSEPPE;
1995-01-01
Abstract
All possible stereoisomers of triols of general formula 6 (R1 = allyl, R2 = Me or allyl) have been synthesized stereoselectively starting from asymmetrized bis(hydroxymethy1)acetaldehyde (BHYMA*), a novel chiral building block prepared through a chemoenzymatic methodology. This goal was realized through a sequence of protecting group-controlled nucleophilic additions and/or reductions performed on two side arms of this versatile building block.File in questo prodotto:
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