Nitrogen-containing heterocycles are widely distributed in nature and essential for life, playing a vital role in the metabolism of all living cells. Among the many nitrogencontaining heterocycles, the pyrazolo[3,4-d]pyrimidine nucleus (Figure 1) is an important drug-like scaffold that is present in many pharmacologically active compounds. This review describes the synthesis of pyrazolo-pyrimidines and their activities as kinase inhibitors.
Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies
SCHENONE, SILVIA;MUSUMECI, FRANCESCA;BRULLO, CHIARA;
2014-01-01
Abstract
Nitrogen-containing heterocycles are widely distributed in nature and essential for life, playing a vital role in the metabolism of all living cells. Among the many nitrogencontaining heterocycles, the pyrazolo[3,4-d]pyrimidine nucleus (Figure 1) is an important drug-like scaffold that is present in many pharmacologically active compounds. This review describes the synthesis of pyrazolo-pyrimidines and their activities as kinase inhibitors.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.