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EnglishNitrogen-containing heterocycles are widely distributed in nature and essential for life, playing a vital role in the metabolism of all living cells. Among the many nitrogencontaining heterocycles, the pyrazolo[3,4-d]pyrimidine nucleus (Figure 1) is an important drug-like scaffold that is present in many pharmacologically active compounds. This review describes the synthesis of pyrazolo-pyrimidines and their activities as kinase inhibitors.
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| Titolo: | Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies |
| Autori: | |
| Data di pubblicazione: | 2014 |
| Rivista: | |
| Abstract: | Nitrogen-containing heterocycles are widely distributed in nature and essential for life, playing a vital role in the metabolism of all living cells. Among the many nitrogencontaining heterocycles, the pyrazolo[3,4-d]pyrimidine nucleus (Figure 1) is an important drug-like scaffold that is present in many pharmacologically active compounds. This review describes the synthesis of pyrazolo-pyrimidines and their activities as kinase inhibitors. |
| Handle: | http://hdl.handle.net/11567/747195 |
| Appare nelle tipologie: | 01.01 - Articolo su rivista |
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