NK cells are the most potent effectors against different tumors in vitro. However, their efficacy in vivo is compromised by suppressive signals delivered by tumor or tumor-associated cells. This study unravels the molecular mechanisms by which melanomas disarm NK cells and offers clues to revert such inhibitory effect.
How melanoma cells inactivate NK cells
PIETRA, GABRIELLA;MORETTA, LORENZO;MINGARI, MARIA CRISTINA
2012-01-01
Abstract
NK cells are the most potent effectors against different tumors in vitro. However, their efficacy in vivo is compromised by suppressive signals delivered by tumor or tumor-associated cells. This study unravels the molecular mechanisms by which melanomas disarm NK cells and offers clues to revert such inhibitory effect.
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