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EnglishThe new combination of ifosfamide and vinorelbine was evaluated in a phase II study of patients with metastatic breast cancer. All the patients had evaluable or measurable lesions resistant to the combination of cyclophosphamide, epidoxorubicin and 5-fluorouracil. Out of 25 patients entered the trial, 7 achieved an objective response (28\%) (95\% C.I. 12-49.3). Ten patients (40\%) experienced stable disease and the remaining patients (30\%) progressive disease. The median time to progression was 4 months (range 2-12+). The activity of the ifosfamide-vinorelbine combination has been demonstrated and the toxicity was acceptable.
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| Titolo: | Phase II study of vinorelbine and ifosfamide in anthracycline resistant metastatic breast cancer. |
| Autori: | |
| Data di pubblicazione: | 1997 |
| Rivista: | |
| Abstract: | The new combination of ifosfamide and vinorelbine was evaluated in a phase II study of patients with metastatic breast cancer. All the patients had evaluable or measurable lesions resistant to the combination of cyclophosphamide, epidoxorubicin and 5-fluorouracil. Out of 25 patients entered the trial, 7 achieved an objective response (28\%) (95\% C.I. 12-49.3). Ten patients (40\%) experienced stable disease and the remaining patients (30\%) progressive disease. The median time to progression was 4 months (range 2-12+). The activity of the ifosfamide-vinorelbine combination has been demonstrated and the toxicity was acceptable. |
| Handle: | http://hdl.handle.net/11567/471687 |
| Appare nelle tipologie: | 01.01 - Articolo su rivista |
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