Background: Osteoporosis and sarcopenia are prevalent chronic diseases in elderly associated with increased morbidity, disability, mortality and outgrowing socio economic burden.1) The demography of aging addresses the focus on effective screening and primary preventive strategies to cope with osteo-sarco-dynapenia in order to decrease the incidence of bone fracture as well as to restrain their overall socioeconomic burden. Objectives: The present study enrolled 50 patients admitted to a transitional care hospital (S.Martino Hospital in Genoa) and set in institutional care (Nursing Home of Genoa) to estimate the prevalence of osteo-sarco-dynapenia through the assessment of quantitative bone ultrasonography (QUS Ge Achilles Lunar) and isometric dynamometer (HG: Hand Grip Strength test) as clinical risk predictors in the examined population. Methods: The features of patients are reported as follow: 35F e 15M with a mean age of 87,6±1,02 years; a mean comorbidity of 3,8±0,2 diseases; previous hip fracture n23 (46%); mean polypharmacy 8,3±0,35 drugs. All the examined patients were submitted to heel ultrasonography assessment (QUS) for osteoporosis and hand grip test (HG) to assess muscle strength. All data are presented as mean ±of standard error and linear and non linear regression analysis; p< 0.05 was considered statistically significant. Results: The results of the present study are listed as follow: HG, Kg: Non fractured subjects: mean 14,3±1 (age adjusted reference >85 yrs: M 22.8-31.3; F 12.9-16.2) Fractured subjects : mean 11±2 (age adjusted reference >85yrs :M 22.8-31.3; F 12.9-16.2) QUS: T-score: mean -4,3± 0,23 ( reference score T score -1.8) According to literature, the data showed a significant negative correlation between aging and HG (r=-0.332; p<0.05) and respectively a significant positive correlation between BUA (broad ultrasound attenuation) and HG (r=0.39;p<0.01) and T score e HG (r=0.354;p<0.05). Conclusions: The study showed the overall prevalence of osteo-sarco-dynapenia in the examined population as well as the effectiveness of QUS and HG as clinical risk predictors.2) Their handiness, feasibility as non invasive tools strongly recommend their application in the geriatric population particularly in residential setting in order to plan extensive screening programs to act effective primary preventive measures. References 1) Cooper C, Atkinson EJ, Jacobsen SJ. Population-based study of survival after osteoporotc fractures. American Journal of Epidemiology.1993;137:1001-1005. 2) Marin F, Gonzales-Marcias J, Diez-Perez A. Relationship between bone quantitative ultrasound and fractures: a metanalysis. Journal of Bone and Mineral Research.2006;21:1126-1135.
Prevalence of osteosarcodynapenia in elderly setting in Nursing Home and transitional care: QUS and HG as clinical risk predictors
MONACELLI, FIAMMETTA;MOLFETTA, LUIGI;ODETTI, PATRIZIO
2011-01-01
Abstract
Background: Osteoporosis and sarcopenia are prevalent chronic diseases in elderly associated with increased morbidity, disability, mortality and outgrowing socio economic burden.1) The demography of aging addresses the focus on effective screening and primary preventive strategies to cope with osteo-sarco-dynapenia in order to decrease the incidence of bone fracture as well as to restrain their overall socioeconomic burden. Objectives: The present study enrolled 50 patients admitted to a transitional care hospital (S.Martino Hospital in Genoa) and set in institutional care (Nursing Home of Genoa) to estimate the prevalence of osteo-sarco-dynapenia through the assessment of quantitative bone ultrasonography (QUS Ge Achilles Lunar) and isometric dynamometer (HG: Hand Grip Strength test) as clinical risk predictors in the examined population. Methods: The features of patients are reported as follow: 35F e 15M with a mean age of 87,6±1,02 years; a mean comorbidity of 3,8±0,2 diseases; previous hip fracture n23 (46%); mean polypharmacy 8,3±0,35 drugs. All the examined patients were submitted to heel ultrasonography assessment (QUS) for osteoporosis and hand grip test (HG) to assess muscle strength. All data are presented as mean ±of standard error and linear and non linear regression analysis; p< 0.05 was considered statistically significant. Results: The results of the present study are listed as follow: HG, Kg: Non fractured subjects: mean 14,3±1 (age adjusted reference >85 yrs: M 22.8-31.3; F 12.9-16.2) Fractured subjects : mean 11±2 (age adjusted reference >85yrs :M 22.8-31.3; F 12.9-16.2) QUS: T-score: mean -4,3± 0,23 ( reference score T score -1.8) According to literature, the data showed a significant negative correlation between aging and HG (r=-0.332; p<0.05) and respectively a significant positive correlation between BUA (broad ultrasound attenuation) and HG (r=0.39;p<0.01) and T score e HG (r=0.354;p<0.05). Conclusions: The study showed the overall prevalence of osteo-sarco-dynapenia in the examined population as well as the effectiveness of QUS and HG as clinical risk predictors.2) Their handiness, feasibility as non invasive tools strongly recommend their application in the geriatric population particularly in residential setting in order to plan extensive screening programs to act effective primary preventive measures. References 1) Cooper C, Atkinson EJ, Jacobsen SJ. Population-based study of survival after osteoporotc fractures. American Journal of Epidemiology.1993;137:1001-1005. 2) Marin F, Gonzales-Marcias J, Diez-Perez A. Relationship between bone quantitative ultrasound and fractures: a metanalysis. Journal of Bone and Mineral Research.2006;21:1126-1135.
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