Benzodiazepines I (NRR1 = NMe2, NEt2, pyrrolidino; R2 = SMe) were prepd. by thiolating benzodiazepinones and methylating the thiones. I (R2 = SMe) were aminated to give I (R2 = NMe2, pyrrolidino, piperidino, morpholino). I (R2 = SMe) were central nervous system depressants and anticonvulsants, whereas I (R2 = amino) were central nervous system stimulants and convulsants.
[1,5-Benzodiazepines. III. Synthesis of 2,4-bisdialkylamino-3H-1,5-benzodiazepines].
BALBI, ALESSANDRO;
1979-01-01
Abstract
Benzodiazepines I (NRR1 = NMe2, NEt2, pyrrolidino; R2 = SMe) were prepd. by thiolating benzodiazepinones and methylating the thiones. I (R2 = SMe) were aminated to give I (R2 = NMe2, pyrrolidino, piperidino, morpholino). I (R2 = SMe) were central nervous system depressants and anticonvulsants, whereas I (R2 = amino) were central nervous system stimulants and convulsants.
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