Even in patients treated with complete resection of multiple lung metastases from sarcomas and systemic chemotherapy, pulmonary recurrence is frequent. This supports the need for a multimodality approach, in which surgery would remove all the detectable tumor burden, while regional chemotherapy would eradicate the microscopic foci. Sarcomas represent an ideal model for pulmonary perfusion, since metastases often remain restricted to the lung, at least during the initial distant spread phase. For the isolated lung perfusion, we adopted the same therapeutic schedule that had already proved to be effective in the regional treatment of limb sarcomas: hyperthermia, TNF and melphalan. The aim of the present study was to assess the feasibility and safety of the multimodality approach, as well as its pulmonary parenchyma toxicity.
METASTASECTOMY AND HYPERTHERMIC ISOLATED LUNG PERFUSION WITH TNF AND MELPHALAN IN THE TREATMENT OF MULTIPLE PULMONARY METASTASES FROM SARCOMAS
DE CIAN, FRANCO
2009-01-01
Abstract
Even in patients treated with complete resection of multiple lung metastases from sarcomas and systemic chemotherapy, pulmonary recurrence is frequent. This supports the need for a multimodality approach, in which surgery would remove all the detectable tumor burden, while regional chemotherapy would eradicate the microscopic foci. Sarcomas represent an ideal model for pulmonary perfusion, since metastases often remain restricted to the lung, at least during the initial distant spread phase. For the isolated lung perfusion, we adopted the same therapeutic schedule that had already proved to be effective in the regional treatment of limb sarcomas: hyperthermia, TNF and melphalan. The aim of the present study was to assess the feasibility and safety of the multimodality approach, as well as its pulmonary parenchyma toxicity.
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