We report that somatostatin receptor (SSTR) 1,2 and 5 activation by selective agonists, causes C6 cell growth arrest through PTPh-dependent dephosphorylation of ERK1/2 in vitro and after xenografting in nude mice. Individual SSTR agonists displayed different effi cacy and potency showing partial synergism by combined treatment. Since most tumor cells express multiple SSTRs, the activation of all the subtypes may grant a better control of cancer growth.
Somatostatin receptor 1, 2 and 5 activation leads to C6 glioma growth arrest in vitro and in vivo: analysis of the intracellular pathways involved
GATTI, MONICA;PATTAROZZI, ALESSANDRA;WURTH, ROBERTO;BARBIERI, FEDERICA;FLORIO, TULLIO
2011-01-01
Abstract
We report that somatostatin receptor (SSTR) 1,2 and 5 activation by selective agonists, causes C6 cell growth arrest through PTPh-dependent dephosphorylation of ERK1/2 in vitro and after xenografting in nude mice. Individual SSTR agonists displayed different effi cacy and potency showing partial synergism by combined treatment. Since most tumor cells express multiple SSTRs, the activation of all the subtypes may grant a better control of cancer growth.
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