Copolymers containing aldehydic, 4-aminobutyl and 6-aminohexyl residues were prepared by radical copolymerization of N,N-dimethylacrylamide (DMAA) with methacrolein and hydrochlorides of 4-(4-aminobutyl)styrene and N-acryloyl-1,6-diaminohexane. Copolymers containing L-lysine, 2-aminoethyl and 4-aminobutyl residues were prepared by copolymerization of the methacryloxyethyl ester of L-Nα,Nε-diBoc lysine, N-acryloyl-N’-Boc-1,2-diaminoethane and N-acryloyl-N’-Boc-1,4-diaminobutane with DMAA followed by deprotection. Some of the prepared copolymers were employed in experiments of gelatin crosslinking also in the presence of copper amine oxidase enzymes.
Synthesis of functionalized vinyl copolymers to use as polymeric crosslinkers in the preparation of gelatin-based scaffolds
POCCI, MARCO;ALFEI, SILVANA;CASTELLARO, SARA;LUCCHESINI, FRANCESCO;BERTINI, VINCENZO
2011-01-01
Abstract
Copolymers containing aldehydic, 4-aminobutyl and 6-aminohexyl residues were prepared by radical copolymerization of N,N-dimethylacrylamide (DMAA) with methacrolein and hydrochlorides of 4-(4-aminobutyl)styrene and N-acryloyl-1,6-diaminohexane. Copolymers containing L-lysine, 2-aminoethyl and 4-aminobutyl residues were prepared by copolymerization of the methacryloxyethyl ester of L-Nα,Nε-diBoc lysine, N-acryloyl-N’-Boc-1,2-diaminoethane and N-acryloyl-N’-Boc-1,4-diaminobutane with DMAA followed by deprotection. Some of the prepared copolymers were employed in experiments of gelatin crosslinking also in the presence of copper amine oxidase enzymes.
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