The synthesis of a new family of A1-adenosine receptor (A1AR) ligands has was performed in a straightforward way. Affinity data at A1AR, A2AAR and A3AR in bovine membranes show that these new compds. bind the A1AR in a selective way over A2AAR and A3AR and one of them presents a very high affinity, probably due to the phenethylamine substituent at C-4.
Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands
SCHENONE, SILVIA;BRUNO, OLGA;FOSSA, PAOLA;RANISE, ANGELO;MENOZZI, GIULIA;MOSTI, LUISA;BONDAVALLI, FRANCESCO;
2001-01-01
Abstract
The synthesis of a new family of A1-adenosine receptor (A1AR) ligands has was performed in a straightforward way. Affinity data at A1AR, A2AAR and A3AR in bovine membranes show that these new compds. bind the A1AR in a selective way over A2AAR and A3AR and one of them presents a very high affinity, probably due to the phenethylamine substituent at C-4.
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