SS analogs may be of interest in the treatment of lymphoproliferative malignancies, although controlled studies are warranted to investigate the efficacy of the current available analogs. A promising approach in refractory patients with SSR positive malignant lymphomas may be radionuclide-targeted therapy. Furthermore, the development of receptor-based localization and antitumor strategies may be extended to other G protein-coupled receptors. This could be valid for two different important reasons: first, neuropeptide receptors homo- and heterodimerization has been recently shown occurring in transfected cell lines and involves different subtypes of SSR, as well as SSR and receptors for dopamine (50-61). Dimer formation seems to enhance or modify the transduction pathway activated by the monomeric receptor. From the other hand, in vivo imaging techniques of tumor via receptors for other well known neuroeptides, such as bombesin, vasoactive intestinal polypeptide, substance P, gastrin, have been already employed to visualize many neoplasms, and ligand-binding studies clearly demonstrated neuroreceptor binding sites in human tumors. Finally, cytotoxic analogs of ligands for these receptors have been developed and displayed an antiproliferative effect in experimental conditions. Whether these new agents can be of value for both diagnostic and therapeutic purposes in lymphoproliferative diseases is still unknown, however, their development represents an innovative and promising perspective.

Role of somatostatin analogues in the management of immunolymphoproliferative diseases

FERONE, DIEGO;ARVIGO, MARICA;
2003-01-01

Abstract

SS analogs may be of interest in the treatment of lymphoproliferative malignancies, although controlled studies are warranted to investigate the efficacy of the current available analogs. A promising approach in refractory patients with SSR positive malignant lymphomas may be radionuclide-targeted therapy. Furthermore, the development of receptor-based localization and antitumor strategies may be extended to other G protein-coupled receptors. This could be valid for two different important reasons: first, neuropeptide receptors homo- and heterodimerization has been recently shown occurring in transfected cell lines and involves different subtypes of SSR, as well as SSR and receptors for dopamine (50-61). Dimer formation seems to enhance or modify the transduction pathway activated by the monomeric receptor. From the other hand, in vivo imaging techniques of tumor via receptors for other well known neuroeptides, such as bombesin, vasoactive intestinal polypeptide, substance P, gastrin, have been already employed to visualize many neoplasms, and ligand-binding studies clearly demonstrated neuroreceptor binding sites in human tumors. Finally, cytotoxic analogs of ligands for these receptors have been developed and displayed an antiproliferative effect in experimental conditions. Whether these new agents can be of value for both diagnostic and therapeutic purposes in lymphoproliferative diseases is still unknown, however, their development represents an innovative and promising perspective.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11567/212021
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