CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishFor a better understanding of protein synthesis and degradation in the human kidney, the arteriovenous difference technique across the kidney, splanchnic organs, and leg muscle was combined with labeled leucine and phenylalanine isotope dilution models. Results indicate that in the postabsorptive state, the protein balance across the human kidney is negative because the rate of leucine release from protein degradation is greater than the amount used for protein synthesis. In the splanchnic bed, net protein balance is neutral since the amount of leucine deriving from protein degradation is similar to the amount utilized for protein synthesis. In the leg muscle, protein degradation exceeds protein synthesis. The kidney exhibits the highest leucine metabolic activity when expressed in terms of total organ leucine content. The estimated fractional protein synthesis rate in the human kidney is about 40% per day (vs. about 2% in muscle and 12% in the splanchnic bed). The human kidney presents high rates of protein turnover and accounts for a significant fraction of whole-body protein degradation, protein synthesis, and leucine oxidation.
Protein turnover in the kidney and the whole body in humans. / G. GARIBOTTO; TESSARI P; ROBAUDO C; ZANETTI M; SAFFIOTI S; VETTORE M; INCHIOSTRO S; SACCO P; DEFERRARI G; TIZIANELLO A. - In: MINERAL AND ELECTROLYTE METABOLISM. - ISSN 0378-0392. - STAMPA. - 23(1997), pp. 185-188.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
| Titolo: | Protein turnover in the kidney and the whole body in humans. |
| Autori: | |
| Data di pubblicazione: | 1997 |
| Rivista: | |
| Citazione: | Protein turnover in the kidney and the whole body in humans. / G. GARIBOTTO; TESSARI P; ROBAUDO C; ZANETTI M; SAFFIOTI S; VETTORE M; INCHIOSTRO S; SACCO P; DEFERRARI G; TIZIANELLO A. - In: MINERAL AND ELECTROLYTE METABOLISM. - ISSN 0378-0392. - STAMPA. - 23(1997), pp. 185-188. |
| Abstract: | For a better understanding of protein synthesis and degradation in the human kidney, the arteriovenous difference technique across the kidney, splanchnic organs, and leg muscle was combined with labeled leucine and phenylalanine isotope dilution models. Results indicate that in the postabsorptive state, the protein balance across the human kidney is negative because the rate of leucine release from protein degradation is greater than the amount used for protein synthesis. In the splanchnic bed, net protein balance is neutral since the amount of leucine deriving from protein degradation is similar to the amount utilized for protein synthesis. In the leg muscle, protein degradation exceeds protein synthesis. The kidney exhibits the highest leucine metabolic activity when expressed in terms of total organ leucine content. The estimated fractional protein synthesis rate in the human kidney is about 40% per day (vs. about 2% in muscle and 12% in the splanchnic bed). The human kidney presents high rates of protein turnover and accounts for a significant fraction of whole-body protein degradation, protein synthesis, and leucine oxidation. |
| Handle: | http://hdl.handle.net/11567/192723 |
| Appare nelle tipologie: | 01.01 - Articolo su rivista |
File in questo prodotto:
http://hdl.handle.net/11567/192723
Copyright © 2021