This review focuses on the immune checkpoint inhibitors (ICIs) in the context of breast cancer (BC) management. These innovative treatments, by targeting proteins expressed on both tumor and immune cells, aim to overcome tumor-induced immune suppression and reactivate the immune system. The potential of this approach is the subject of numerous clinical studies. Here, we explore the key studies and emerging therapies related to ICIs providing a detailed analysis of their specific and combined use in BC treatment.
The landscape of combining immune checkpoint inhibitors with novel Therapies: Secret alliances against breast cancer
Rebaudi, Federico;De Franco, Fabiana;Goda, Rayan;Obino, Valentina;Vita, Giorgio;Baronti, Camilla;Pitto, Francesca;Fenoglio, Daniela;Poggio, Francesca;Fregatti, Piero;Melaiu, Ombretta;Bozzo, Matteo;Candiani, Simona;Greppi, Marco;Pesce, Silvia;Marcenaro, Emanuela
2024-01-01
Abstract
This review focuses on the immune checkpoint inhibitors (ICIs) in the context of breast cancer (BC) management. These innovative treatments, by targeting proteins expressed on both tumor and immune cells, aim to overcome tumor-induced immune suppression and reactivate the immune system. The potential of this approach is the subject of numerous clinical studies. Here, we explore the key studies and emerging therapies related to ICIs providing a detailed analysis of their specific and combined use in BC treatment.
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