Background: Purified Cytoplasm of Pollen (PCP) is a non-hormonal herbal remedy used to manage vasomotor symptoms (VMS), sleep and mood disorders in menopausal women not relying on Hormone Replacement Therapy (HRT). Many studies demonstrated its efficacy and safety in post-menopause but few data are available about peri-menopause. Methods: This is a multicentre prospective observational study on Italian symptomatic women in peri- and post-menopause referring to gynaecology clinics of different areas of Italy, evaluating the effects of PCP therapy on hot flashes (HFs) and other parameters included in the Greene Climacteric Scale (GCS). Results: We recruited 108 peri- and post-menopausal women (mean age 53.8 ± 4 yrs), evaluating them at baseline (V0) and after 3 months of PCP treatment (V1). Basal median value of all items of GCS did not differ among all subjects. We found a significant improvement of HFs (p< 0.0001) and night sweats (p< 0.0001) between V0 and V1. Additionally, all items of GCS apart from loss of sensitivity to limbs (p=0.0746) significantly ameliorated after PCP therapy (p< 0.05). Conclusions: According to these findings, PCP may be considered as an efficacious alternative non-hormonal treatment for the management of VMS as well as mood and sleep disturbances in both peri- and post-menopause.

The benefits of purified cytoplasm of pollen in reducing menopausal symptoms in peri- and post-menopause: an Italian multicentre prospective observational study

Cagnacci, Angelo
2021

Abstract

Background: Purified Cytoplasm of Pollen (PCP) is a non-hormonal herbal remedy used to manage vasomotor symptoms (VMS), sleep and mood disorders in menopausal women not relying on Hormone Replacement Therapy (HRT). Many studies demonstrated its efficacy and safety in post-menopause but few data are available about peri-menopause. Methods: This is a multicentre prospective observational study on Italian symptomatic women in peri- and post-menopause referring to gynaecology clinics of different areas of Italy, evaluating the effects of PCP therapy on hot flashes (HFs) and other parameters included in the Greene Climacteric Scale (GCS). Results: We recruited 108 peri- and post-menopausal women (mean age 53.8 ± 4 yrs), evaluating them at baseline (V0) and after 3 months of PCP treatment (V1). Basal median value of all items of GCS did not differ among all subjects. We found a significant improvement of HFs (p< 0.0001) and night sweats (p< 0.0001) between V0 and V1. Additionally, all items of GCS apart from loss of sensitivity to limbs (p=0.0746) significantly ameliorated after PCP therapy (p< 0.05). Conclusions: According to these findings, PCP may be considered as an efficacious alternative non-hormonal treatment for the management of VMS as well as mood and sleep disturbances in both peri- and post-menopause.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11567/1083077
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact